Analysis Of Brain Microstructural Changes In Patients With Ischemic Stroke Rehabilitated By Manipulators By Diffusion Kurtosis Magnetic Resonance Imaging

Objective: to explore the changes of brain microstructure in patients with ischemic stroke treated by manipulator based on diffusion kurtosis imaging((DKI)).Methods:fifteen patients with ischemic stroke with wrist and hand dysfunction diagnosed in our hospital from December 2018 to December 2019 were collected,and the manipulator rehabilitation exercise was carried out for 4 weeks.The patients were scanned by routine head scan and diffusion sequence before and after rehabilitation,and processed with DKE and other software.The average kurtosis coefficient(MK),average diffusion coefficient(MD),axial kurtosis coefficient(K?),radial kurtosis coefficient(K?)and partial anisotropy fraction(FA)were calculated and the corresponding images were generated.The parameters of brainstem,splinter of corpus callosum,bilateral internal capsule,bilateral hippocampus,bilateral thalamus and bilateral precentral gyrus cortex were measured.Paired t-test was used to analyze and compare the two groups of data.to determine whether there is a difference between the two groups of data and use Siemens workstation to track the nerve fiber bundle.Results:(1)compared with those before treatment,the MK of brainstem,splinter of corpus callosum,bilateral internal capsule,bilateral hippocampus,bilateral thalamus and bilateral temporal lobe cortex increased,MD decreased,K ? increased,K ? increased,and the difference was statistically significant(P < 0.05).The FA values of brainstem,splenium of corpus callosum,bilateral internal capsule,ipsilateral hippocampus,bilateral thalamus and bilateral precentral gyrus cortex after treatment were significantly higher than those before treatment(P < 0.05).There was no significant difference in FA value of contralateral hippocampus.(2)the changes of nerve fiber bundle conduction pathway were observed directly before andafter treatment by nerve fiber bundle tracking technique.Conclusion: this study can quantitatively,intuitively and non-invasively observe the changes of brain microstructure of stroke patients rehabilitated by manipulators through diffusion kurtosis imaging sequence(DKI),and provide timely diagnosis and treatment information and timely adjustment plan for clinic.