| Objective:To observe and evaluate the clinical efficacy and safety of clinical application of ma fu wen bi tang in the treatment of diabetic peripheral neuropathy(cold coagulation blood stasis,venation bi bi syndrome)with the theoretical opportunity of "cold coagulation blood stasis,venation bi obstruction".Methods: A total of 60 patients with DPN who met the diagnostic criteria for diabetic peripheral neuropathy(cold coagulation and blood stasis,vein obstruction syndrome)were selected from the outpatient department and ward of affiliated hospital of changchun university of traditional Chinese medicine from October 2018 to October 2019.Patients were randomly divided into treatment group and control group(30 patients in each group).Both groups were treated with western medicine,and the control group was given mecobalamin tablets orally.The treatment group was treated with ma fu wen bi tang for 3 courses of treatment(1 course for 4 weeks).The changes of single syndrome score,total score,vibration sense of tuning fork,touch of 10 g nylon wire and sensory threshold were observed in the two groups of patients before and after treatment,and the results before and after treatment were compared and analyzed to draw a conclusion.Results:1.The total effective rate of the treatment group and the control group was 86% and70%,respectively,and the treatment group was better than the control group(P<0.05).The effect of the treatment group was better than that of the control group2.After treatment,the scores of major and minor TCM symptoms in the treatment group were all reduced(P<0.01).In the control group,except for numbness,callousness and limb weakness,there was no significant change(P>0.05),the scores of other major and minor symptoms were all reduced(P<0.05).Comparison between groups: all P values were <0.05,indicating that the decreasing degree of TCM symptom score in the treatment group was significantly better than that in the control group.3.In terms of improving the total TCM syndrome of patients,the therapeutic effect of the treatment group was significantly better than that of the control group.4.Intra-group comparison: the vibration sensation of tuning fork could be improved in both groups with significant statistical significance(P < 0.01).Comparison between groups: the treatment group was superior to the control group(P < 0.05),indicating that the treatment group had more treatment advantages.5.Intra-group comparison: The tactile measurement of patients in both groups was significantly improved after treatment and the difference was significant(P < 0.01,P <0.05).Comparison between groups: In terms of improving patients’ sense of touch,the treatment group was superior to the control group,with statistically significant difference(P < 0.05).6.Intra-group comparison: after treatment,there were significant differences in various neurosensory thresholds in the treatment group(P<0.05).In the control group,except for the right median nerve(P>0.05),there were significant differences in other nerves(P<0.05).Comparison between groups: in terms of nerve improvement,the difference of the left sural nerve was not significant(P>0.05),while the difference of the other nerves was significant(P < 0.05).7.During the treatment period,the two groups of patients did not show symptoms of hypoglycemia,the patients’ vital signs were stable,and there were no abnormalities in routine examination items such as blood routine examination,liver and kidney function.Conclusion:Ma fu wen bi tang is effective in the treatment of diabetic peripheral neuropathy with cold coagulation blood stasis and biliary obstruction syndrome of traditional Chinese medicine.It can not only significantly improve the clinical symptoms and signs of patients,but also have a good impact on blood glucose level.It is also safe in the treatment process and worthy of clinical application. |
