Efficacy And Safety Of BLQ Combined With TACE In The Treatment Of Advanced HCC

Objective Through the analysis of big data network,it was found that the prescription of famous old Chinese medicine doctors for HCC was regular and formed.According to its characteristics,it was named BLQ.By comparing the indicators of BLQ group oral combined with transcatheter arterial chemoembolization(TACE)and TACE alone in the treatment of advanced HCC,the clinical functional status,efficacy and safety indicators of patients after treatment were observed to determine the efficacy and safety of BLQ group combined with TACE in the treatment of advanced HCC.Methods 1.Clinical data: 60 patients with primary liver cancer who met the inclusion and exclusion criteria were selected as the study subjects,and were divided into 2 groups by computer random number generator.30 cases in the conventional treatment group,and 30 cases in BLQ group.After the grouping was completed,the age,gender,KPS score,BCLC stage,maximum solid tumor diameter and Ccr of the two groups were recorded and compared,showing no significantdifference(P>0.05),confirming the comparability.The blind method was single blind method,and BLQ were packaged with plastic packaging.2.Treatment conventional treatment group: local anesthesia,ct-guided Selinger technique,TACE,fully hydrated contrast agent,hemostasis,acid production and stomach protection,and liver detoxification.Give 20 g of licorice root decoction in water,make Chinese medicine placebo.BLQ group: BLQ was added to the conventional treatment plan of the control group for treatment.The composition of BLQ prescription is as follows: astragalus 30 g,poria coaling 20 g,fructus psoraleae 15 g,medlar 15 g,ganoderma lucidum 10 g,jiao hawthorn 10 g,shenqu 10 g,fructus aurantii 10 g,baiying30g,centipede 2,khumbu 10 g,rhizoma zedoary 10 g,chingi mushroom 20 g,coix seed 10 g,bupleurum 15 g,turtle a 15 g,wormwood 10 g,August zha 15 g,Yin Chen 15 g,banzhihua 20 g.The patient was advised to take 1 dose of 400 ml water decoction every day after TACE surgery,divided into morning and evening,and continued to take the medicine for at least 3 months after TACE surgery.During the study period,patients can exercise properly to avoid spicy stimulation and fatigue.If feel unwell,they can report to the doctor in time and withdraw from the study if necessary.3.Observation indexes: 3.1 Therapeutic safety index:postoperative nausea and vomiting,fever(>37.3?,last 3 days or more),pain(NRS score ?4 points),liver and kidney injury,bone marrow suppression and other major clinical symptoms were observed.3.2 Outcome indicators after treatment :3 months after treatment,child-pugh score and KPS score were evaluated.Reviewalpha-fetoprotein;Abdominal CT was reexamined to compare the diameter of solid tumor and progression-free survival(PFS).The effectiveness evaluation method is based on nimodipine method.Results 1.Comparison of the number and incidence of clinical complications: there were significant differences in the incidence of postoperative fever,nausea and vomiting,liver and kidney injury,and bone marrow suppression between the two groups,and the BLQ group was lower than the conventional treatment group(P<0.05).However,there wasn't significant difference in the incidence of postoperative abdominal pain between the two groups(P>0.05).2.Comparison of anti-tumor clinical efficacy: after treatment,the diameter of solid tumor and alpha-fetoprotein could be reduced in both groups,(P<0.05).There were also significant differences in the efficacy of the two groups,and the BLQ group was better than the conventional treatment group(P<0.05)?PFS(95%CI),the BLQ group was superior to the conventional treatment group(P<0.05).3.Comparison of clinical functional status: after treatment,KPS scores of patients in both groups were improved compared with those before surgery,and the difference was statistically significant(P<0.05).After treatment,the KPS score of the BLQ group was higher than that of the conventional treatment group,and the difference was statistically significant,(P<0.05)4.Comparison of liver reserve function: after treatment,child-pugh scores of patients in both groups were decreased compared with those before surgery,and the difference was statistically significant(P<0.05).In addition,the child-pughscore of the BLQ group was lower than that of the conventional treatment group,and the difference was statistically significant(P<0.05)5.Comparison of psychological state: the SAS and SDS of patients in the BLQ program group were lower than those before,and the difference was significant(P<0.05).There was no significant difference between the SAS score of the patients in the conventional treatment group and that before treatment(P<0.05),while the SDS score was higher than that before treatment(P<0.05).Comparison between groups showed that after treatment,the SAS score of patients in the BLQ regimen group was significantly lower than that of patients in the conventional treatment group,and the SDS score of patients in the BLQ regimen group was also lower than that of patients in the conventional treatment group(P<0.05).Conclusion In the treatment of advanced HCC,TACE can reduce the level of AFP,improve the KPS score,improve the liver reserve function,and improve the anxiety and depression of patients.For patients who are not suitable for surgical treatment,TACE has its advantages.Combined with BLQ prescription,it can achieve better therapeutic effect.It can reduce the clinical side effects of TACE,improve the quality of life,and obtain better clinical efficacy.