| Objective:To investigate the understanding of TCM on obesity type 2 diabetes in Chinese medicine,and to objectively evaluate the clinical efficacy and safety of Shenshu Heye Decoction on obesity type 2 diabetes with spleen deficiency and phlegm-turbidity syndrome.It provides a theoretical reference for clinical treatment of obese type 2 diabetes with spleen deficiency,phlegm and turbidity syndrome,and at the same time provides effective guidance for actual medication.Methods:Randomized and controlled research methods were used to randomly divide patients with obesity type 2 diabetes and spleen deficiency and phlegm syndrome into a treatment group and a control group of 30 patients.① Control group:given conventional Western medicine treatment:given oral hypoglycemic drugs:metformin tablets,0.85g,twice daily,oral;saxagliptin,5mg,once daily,oral,atorvastatin,10mg,per Once a day,oral.②Therapeutic group:add Shenshuheye decoction to the patients on the basis of the control group at the same time,the water frying uniform,daily,morning and evening twice a dose of drug.③The two groups of patients received lifestyle intervention after admission.The treatment in both groups took 4 weeks as a course of treatment,and a total of 3 courses of treatment were observed.Observe the clinical efficacy and safety of the weight,waist-to-hip ratio,BMI,blood glucose,blood lipids,insulin-related indicators,TCM clinical symptoms,TCM syndrome scores,etc.of the two groups of patients before and after treatment.Results:Before treatment the baseline data of gender,age,and disease duration of the two groups were not statistically different after statistical processing,and were comparable(P>0.05)①Traditional Chinese Medicine Symptoms:The comparison of syndrome scores between the two groups showed significant improvement before and after treatment.Statistical analysis((P<0.05 或 P<0.01))suggested statistical significance.Comparison between groups,through statistical analysis(P<0.01),showed statistical significance,the treatment group was significantly better than the control group.② TCM Syndrome Points:Both groups can improve TCM syndromes and relieve clinical symptoms after treatment.The total effective rate of TCM syndromes in the treatment group is 90.00%,and the total effective rate in the control group is 60.00%.The overall effective rate of the treatment group was better than that of the control group(P<0.01)③ Glucose index:Fasting blood glucose,postprandial blood glucose,and glycated hemoglobin were significantly reduced after treatment in both groups(P<0.05);fasting blood glucose,postprandial blood glucose,and glycated hemoglobin decreased significantly in the treatment group after treatment(P<0.01).④Insulin-related indicators:Fasting insulin decreased after treatment and insulin sensitivity index increased in both groups(P<0.05);insulin sensitivity index in the treatment group was significantly higher than that in the control group(P<0.01).⑤ Obesity-related:indicators:After treatment in the two groups of patients,the treatment group’s four indicators of BMI,weight,waist circumference,and waist-to-hip ratio were significantly lower than before treatment(P<0.05),while the control group was only at Two indicators improved(P<0.05).After treatment,the four indexes of BMI,weight,waist circumference and waist-to-hip ratio were significantly lower than that of the control group(P<0.01).⑥ Blood lipid index:After treatment,the levels of TG,TC and LDL-C in the treatment group were significantly lower than those in the control group(P<0.05).⑦Comparison of the curative effect of the two groups of patients after treatment:The total effective rate of the treatment group was 86.67%.The total effective rate of the control group was 40.00%,and the total effective rate of the treatment group was significantly higher than that of the control group(P<0.01).⑧Safety index:The blood,urine,feces routine and liver and kidney function indexes of the two groups of patients are in the normal range,there is no obvious adverse reaction,and the safety is good.Conclusions:Shenshu Heye Decoction can significantly reduce the blood glucose and insulin-related indexes of obese type 2 diabetes patients,and can improve various clinical symptoms.In addition,it can reduce weight,waist-to-hip ratio,improve BMI index,and reduce fat It has obvious advantages,remarkable curative effect,high reliability and safety,no side effects,and important clinical value and social value. |
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