| Objective:This topic to observe and evaluate the heat dehumidification pain fluid internal and joint type heat by wind ointment topical treatment of rheumatic fever bi mild-to-moderate knee osteoarthritis clinical efficacy and safety of preliminary evaluation heat dehumidification pain fluid internal and heat by wind paste the advantage of the treatment of early metaphase knee osteoarthritis,provide pure traditional Chinese medicine treatment of mild-to-moderate KOA with evidence-based medicine.Methods:according to the inclusion criteria,this study screened in March2019 to December 2019,guangxi university first affiliated hospital of traditional Chinese medicine doctor during orthopaedic outpatient service into standard patients,syndrome type belong to the type of early metaphase KOA certification of rheumatic fever patients,standard reference in 2010,the state administration of traditional Chinese medicine syndrome diagnosis knee bi disease(KOA)diagnosis and treatment plan,the western medicine diagnostic criteria with reference to the Chinese medical association in 2010 rheumatology branch the diagnosis and treatment of bone arthritisguidediagnosis and treatment schemes,screening of early metaphase KOA patients a total of 60 cases.A randomized controlled study was conducted,which was divided into 2 groups according to the numerical random grouping method.In the experimental group,30 cases were treated with heat-clearing and dehumidification analgesic solution combined with heat-clearing and wind-clearing ointment.In the control group,30 patients were given sodium hyaluronate injection and acetaminophen tablets orally.Before treatment:-14 days to 0 days.The treatment cycle of both groups was one course of 5 weeks,and the end of treatment was 5 weeks.The visual analog score(VAS)and WOMAC osteoarthritis index score were used as the main indicators before and after treatment,and the high-frequency ultrasonic change assessment(joint effusion volume,synovial thickness)was used as the secondary efficacy indicators,and the total clinical efficiency after treatment was calculated.The time nodes collected were before and after treatment.Before and after treatment,venous blood samples of both groups were tested for liver function and renal function to evaluate the safety of the above two methods.All data collected and recorded were statistically analyzed using SPSS22.0 statistical software.Results:a total of 60 patients were included in this study,and the treatment and follow-up were completed on time without shedding.After statistical analysis,there was no significant difference between the two groups in age,gender,profile and K-L imaging classification(P>0.05).After the course oftreatment,the symptoms of the patients in the two groups were improved,including the control group: 1 case of clinical control,14 cases of obvious effect,11 cases of effective effect,and 4 cases of ineffective effect,with a total effective rate of 87%.Experimental group: 2 cases of clinical control,24 cases of obvious effect,1 case of effective effect,3 cases of ineffective effect,the total effective rate is 90%.In 5 weeks after treatment,compared two groups of patients with pain VAS scores,knee function WOMAC score and joint effusion quantity,the thickness of the synovial membrane,the experimental group is better than that of control group,the difference was statistically significant(P < 0.05),two groups to compare the above observation indexes before and after treatment,the curative effect is better than the before treatment,after treatment differences statistically significant(P < 0.05).There was no significant difference in ALT,AST and SCR and BUN between the two groups before and after treatment(P>0.05).Conclusions:1.Endothermic dehumidification zhitong solution combined with external application of qingrezhifeng ointment and sodium hyaluronate injection combined with oral acetaminophen tablets in the treatment of rheumatic heat numbness early and middle stage knee osteoarthritis have a good short-term effect on the improvement of knee joint pain symptoms.2.The clinical efficacy of heat-clearing,dehumidification and analgesia solution taken internally combined with heat-clearing and wind-clearing ointment applied externally in the treatment of rheumatic and heat-numbingmild and moderate genu osteoarthritis was better than that of sodium hyaluronate injection combined with oral acetaminophen tablets.3.Internal administration of heat-clearing,dehumidification and analgesia solution combined with external application of heat-clearing and wind-clearing ointment has the functions of clearing clearing damp,promoting bi and analgesia,relaxing the tendons and activating collateralism.it has a good clinical safety for mild and moderate rheumatic heat and numbness genu osteoarthritis. |
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