The Effects Of Repetitive Transcranial Magnetic Stimulation On Executive Function In Patients With Methamphetamine Dependence

Objective:To understand the difference of executive function between methamphetamine(MA)addicts and healthy adults,to analyze whether there is executive function impairment in MA addicts,and to explore the effect of repetitive transcranial magnetic stimulation on executive function of MA addicts,so as to provide theoretical basis for the innovation of MA drug treatment program.Methods:60 cases of male patients with MA dependence were selected as the MA dependent group and randomly divided into the observation group(high-frequency rTMS)and the control group(without rTMS),each group had 30 cases.At the same time,60 male healthy adults were recruited as the healthy group,whose age and years of education were matched with those of the MA dependent group.The experimental steps were as follows:(1)the executive function in the MA dependent group(60 cases)and the healthy group(60 cases)were measured and compared through Behavior Rating Inventory of Executive Function-Adult Version(BRIEF-A)and Stroop Color Word Test(SCWT).(2)the observation group and the control group in the MA dependent group were respectively subjected to high-frequency rTMS and without rTMS intervention,the stimulation site was left DLPFC,the stimulation frequency was 10 Hz,the stimulation intensity was 100%,3 times a week for 4 weeks,a total of 12 times.After the intervention,the executive function of the two groups was measured by BRIEF-A and SCWT,and compared and analyzed the executive function of the observation group,the control group and healthy group before and after the intervention.Results:(1)By comparing the executive function of the MA dependent group and the healthy group,the results of BRIEF-A showed that the GEC,BRI and MI and nine factors(Inhibit,Shift,Emotional Control,Self-Monitor,Initiate,Working Memory,Plan/Organize,Task Monitor,Organization of Materials)score of the MA dependent group were higher than that of the healthy group(P < 0.05);the results of SCWT showed that the correct reactions of the MA dependent group were lower than that of the healthy group(P<0.05),and the average reaction time were higher than that of the healthy group(P<0.05).(2)By analyzing the executive function before and after intervention in the observation group,the control group and the healthy group,the results of BRIEF-A including the GEC,BRI and MI and nine factors(Inhibit,Shift,Emotional Control,Self-Monitor,Initiate,Working Memory,Plan/Organize,Task Monitor,Organization of Materials)score and the results of SCWT including the correct reactions and the average reaction time between observation group and control group had no significant differences(P>0.05).After the intervention,the results of BRIEF-A showed that the GEC,BRI and MI and nine factors(Inhibit,Shift,Emotional Control,Self-Monitor,Initiate,Working Memory,Plan/Organize,Task Monitor,Organization of Materials)score of the observation group were lower than that of the control group and before the intervention(P<0.05);the results of SCWT showed that the correct reactions of the observation group higher than that of the control group and before the intervention(P<0.05),and the average reaction time of the observation group were lower than that of the control group and before the intervention(P<0.05).In the control group,the results of BRIEF-A including the GEC,BRI and MI and nine factors(Inhibit,Shift,Emotional Control,Self-Monitor,Initiate,Working Memory,Plan/Organize,Task Monitor,Organization of Materials)score and the results of SCWT including the correct reactions and the average reaction time between before and after intervention had no significant differences(P>0.05).By comparing observation group after the intervention and health group,after the intervention,the results of BRIEF-A including the GEC,BRI and six factors(Inhibit,Shift,Emotional Control,Self-Monitor,Initiate,Plan/Organize)score and the results of SCWT including the correct reactions and the average reaction time between observation group and health group had no significant differences(P>0.05).Conclusion:(1)MA dependencies can cause executive function impairment.(2)After existing treatment,rTMS can improve the executive function of patients with MA dependence,but whether it can be improved to a healthy level requires further research.