Meta-Analysis Of The Influence Of Microvascular Invasion On The Prognosis Of Hepatocellular Carcinoma

Objective:The short-term and long-term prognostic outcomes of postoperative hepatocellular carcinoma with microvascular invasion and without microvascular invasion were analyzed using a meta-analysis.Methods:A systematic review of all published articles on microvascular invasion following hepatocellular carcinoma surgery from 1990 to December 2018.Search the following English databases:Pubmed,Cochrane Library,and Embase;search the following Chinese databases:China Knowledge Network(CNKI),Wanfang Data,and China Biomedical Literature Database.Data were collected that met the inclusion criteria,and statistical analysis was performed using Review Manager 5.3 software and STATA 12.0 software.The following were used as outcome measures:overall survival rate at 1,3,and 5 years,and recurrence-free survival at 1,3,and 5 years postoperatively.P<0.05 was considered statistically significant.Results:A total of 21 articles were included(16 in English and 5 in Chinese).Pathological specimens were obtained after hepatectomy or after liver transplantation.Meta-analysis showed that the overall survival rate of MVI(-)group was superior to MyI(+)group at 1,3,and 5 years after hepatectomy,and the recurrence-free survival rate of MVI(-)group after hepatectomy was performed Higher than MVI(+)group;overall survival rate after liver transplantation,RR=0.61,95%CI(0.50,0.74),indicating that the 5-year overall survival rate of MVI(+)group was 0.61 times in MVI(-)group.Three-year recurrence-free survival after liver transplantation,RR=0.76,95%CI(0.72,0.80),indicating that the 3-year recurrence-free survival rate of the MVI(+)group was 0.76 times that of the MVI(-)group.Conclusion:The overall survival rate and recurrence-free survival rate in the MVI(-)group were better than those in the MVI(+)group after hepatectomy.The 5-year overall survival rate and 3-year recurrence-free survival rate after liver transplantation The MVI(-)group was higher than the MVI(+)group,and MVI was a predictor of poor prognosis after hepatocellular carcinoma.