The Association Between 25-hydroxy Vitamin D And Renal Injury In Systemic Lupus Erythematosus Patients

Objective: To investigate the relationship between serum 25-hydroxyvitamin D [25-(OH)-D] and renal impairment in patients with Systemic Lupus Erythematosus(SLE).Methods: This retrospective study involved 181 SLE patients who were first time diagnosed in the First Affiliated Hospital of Xinjiang Medical University from 2018 to2019.All patients were divided into lupus nephritis group(LN group)and non-lupus nephritis group(n-LN group)based on the presence or absence of combined renal damage.Results: The serum levels of 25-(OH)-D in SLE patients were significantly different from those in the healthy control group.The serum levels of 25-(OH)-D in SLE patients were significantly lower than those in the healthy control group.The serum levels of 25-(OH)-D in the LN group were significantly lower than those in the n-LN group.Moreover,in the LN group,25-(OH)-D was positively correlated with complement C3 and complement C4,but negatively correlated with cystatin C,blood urea nitrogen and blood uric acid.In addition,25-(OH)-D was significantly correlated with urinary protein for 24 hours.ROC curve was used to analyze the evaluation effect of 25-(OH)-D on disease activity in SLE patients.The area under the curve was 0.700(95%CI: 0.585-0.815,P=0.003).Conclusions: 25-(OH)-D is associated with LN disease activity in SLE patients and is associated with C3 and C4 in LN patients.It is suggested that 25-(OH)-D has certain clinical significance in reflecting the status of renal damage and evaluating the activity of disease in SLE patients.