The Relationship Between VKORC1,GGCX Gene Polymorphism And Stroke Caused By Atrial

Objective: To study the correlation between rs9923231 polymorphism at VKORC1 gene locus and rs2592551 polymorphism at GGCX gene locus and stroke caused by atrial fibrillation.To provide genetic evidence for the pathogenesis of stroke caused by atrial fibrillation,and to provide better prevention and treatment strategies for patients with stroke caused by atrial fibrillation.Methods: 50 patients with atrial fibrillation-induced stroke were included retrospectively and consecutivly in the Sixth Clinical College of Xinjiang Medical University as the case group(26 males and 24 females)from October 2017 to June 2019.At the same time,100 healthy people matched with gender,age,and ethnicity were included as control groups(48 males and 52 females).Basic information such as gender,age,hypertension,coronary heart disease,and hyperlipidemia were recorded in the two groups.Blood samples are labeled for preservation,DNA extraction,DNA quality inspection,DNA amplification after quality inspection,genotyping and SNP typing on DNA,and Hardy-weinberg heredity The balance test determines whether the sample can represent the population.SPSS software is used to analyze the different genotype frequencies and different allele frequencies of the two SNP.Results:The distribution of rs9923231 genotype frequency of VKORC1 gene in the stroke group was statistically significant(P < 0.05),and rs2592551 genotype frequency of GGCX gene in the stroke group was not statistically significant(P>0.05).Conclusion: The rs9923231 polymorphism of VKORC1 gene is related to the incidence of stroke caused by AF,while the rs2592551 polymorphism of GGCX gene is not related to the incidence of stroke caused by AF.