Sijunzi Decoction And Danshen Yin For Heart Failure With Normal Ejection Fraction(Qi Deficiency And Blood Stasis Type) Clinical Research

Objective: To observe the clinical efficacy and safety of Sijunzi Decoction and Danshen Yin combined with conventional western medicine in the treatment of patients with heart failure with normal ejection fraction(qi deficiency and blood stasis type).Methods: 66 patients with diagnosis of heart failure with normal ejection fraction(qi deficiency and blood stasis type)a clinic or hospital were randomly divided into conventional western treatment group(control group)and the Sijunzi Decoction and Danshen Yin combined with conventional western medicine treatment group(observation group),the course of treatment was 14 days.To observation the total scores of TCM symptoms,N-terminal brain natriuretic peptide precursor(NT-proBNP),soluble growth-stimulating expression gene 2 protein(sST2),echocardiogram(LVEF,LAD,IVSD,LVPWD,LVEDD,LVESD,E/A,E/E,),6-minute walk test(6MWT),Lee’s heart failure score,quality of life assessment,NYHA cardiac function rating and heart rate,blood pressure,blood routine,liver and kidney functional safety indicators.Results: 1.Comparison of the two groups before treatment:TCM symptom scores,NT-proBNP,sST2,echocardiography,6MWT,Lee’s heart failure score,NYHA cardiac function rating,quality of life assessment and safety index baseline balance(P>0.05),which is comparable.2.Comparison before and after treatment:(1)TCM symptom scores,NT-proBNP,sST2 and Lee’s heart failure scores were lower in the two groups after treatment than before(P<0.05),and the difference was statistically significant;(2)After treatment,the LVEF and E/Aof the two groups increased,E/E,,LAD,LVEDD and LVESD decreased.The IVSD and LVPWD in the observation group were lower than those before treatment(P<0.05),and there was no significant difference between the IVSD and LVPWD of the control group and before treatment(P>0.05);(3)Cardiac function and TCM symptoms efficacy,6MWT,and quality of life scores of the two groups improved after treatment(P<0.05),and the differences were statistically significant;(4)After treatment,the heart rate,blood pressure,blood routine,liver and kidney function and other safety indicators were not significantly different than beforetreatment(P>0.05).Indicating that Sijunzi Decoction and Danshen Yin in the treatment of HFNEF(qi deficiency and blood stasis type)is still effective and the patient’s safety is good.3.Comparison between the two groups after treatment:(1)TCM symptom score,NT-proBNP and sST2 of the observation group were lower than those of the control group(P<0.05),and the differences were statistically significant;(2)LVEF,E/Aof the observation group were higher than the control group,E/E,LAD,LVEDD,LVESD,IVSD,LVPWD were smaller than the control group(P<0.05),the difference was statistically significant;(3)Cardiac function and TCM symptoms efficacy,6MWT and quality of life assessment,those score scale was significantly improved compared with the control group(P<0.05),and the difference was statistically significant;(4)There were no significant adverse effects reaction and blood pressure,heart rate,blood routine,liver and kidney function of the two groups of patients were not significantly abnormal(P>0.05).Conclusion: Sijunzi Decoction and Danshen Yin combined with conventional western medicine are more effective in alleviating clinical symptoms and ventricular remodeling,improving cardiac function,quality of life and prognosis of patients with heart failure with normal ejection fraction(qi deficiency and blood stasis type)compared with the western medicine group.It has advantages and safety.