Clinical Observation Of Qingshen Granule On Cure Of Renal Anemiaat 3-5 Stage Of Chronic Kidney Disease Damp-heat Syndrome Patient

Objective:By observing the effect of Qingshen granule on renal anemia in patients with CKD3-5(damp-heat partial type),we can deepen the understanding of TCM on the etiology,pathogenesis and diagnosis and treatment of renal anemia,and promote the clinical application of TCM.Methods:Through the clinical observation method,the included 60 cases were all from the renal anemia(non-dialysis)patients from the First Affiliated Hospital of Anhui University of Chinese Medicine between february 2018 and december 2019,and met the criteria for inclusion of renal anemia(non-dialysis).The trial group and the control group were 30 each.in addition to routine treatments such as controlling blood pressure,blood sugar,correcting acidosis and electrolyte disorders,30 patients in the control group were treated with folic acid tablets 15mg/d and iron polysaccharide complex capsules of 0.15g/d oral administration and erythropoietin 10000IU/week subcutaneous injection and traditional Chinese medicine enema.in the trial group,30 cases were given qingshen granule warm water on the basis of treatment in the control group,3 times per day,1 pack(10g)each time,and the course of treatment lasted for a total of 12 weeks.To observe the TCM syndrome score,anemia-related indicators,renal function index and inflammatory indicators of the test group and the control group before and after treatment,to compare the clinical effect,and to observe and record the possible adverse reactions of the patients during the treatment.Data processing was analyzed by SPSS 21.0 statistical software.Results:1.The total effective rate of the test group was 86.67%,and that of the control group was 63.33%.The efficacy of the two groups was statistically significant(P<0.05).2.The experimental group was better than the control group in terms of overall chinese medicine curative effect,the difference was statistically significant(p <0.05).the experimental group was more obvious than the control group in improving the clinical symptoms of patients with renal anemia such as pale or yellow,fatigue,anorexia.3.The average water of RBC,HCT,Hb,SF and TSAT in the post-treatment test group and the control group were higher than those before treatment,and the results of the test group were statistically significant(P <0.05).4.The results were statistically significant in improving renal function such as serum creatinine,cystatin C,glomerular filtration rate(GFR)and inflammatory indicators hypersensitive C-reactive protein(hs-CRP)(P<0.05).Conclusion:1.Clear kidney particles both in their treatment of kidney disease,can to a certain extent,improve the clinical symptoms and signs of patients with renal anemia.2.In addition to improving renal function and inflammatory indicators hs-CRP,Qingshen granule can also improve the anemia-related indicators.