| Purpose:To investigate the correlation between abdominal aortic calcification and TCM syndromes and clinical indexes in stage 3-5non-dialysis patients with chronic kidney diseaseMethod:Single center,cross-sectional study was used.Data of non-dialysis patients with chronic kidney disease 3-5 who were fol lowed up regularly in the department of nephrology and nutritio n of Hubei Hospital of Traditional Chinese Medicine from Septem ber 2018 to January 2020 were collected(including general cond itions,basic diseases,data of four diagnosis and laboratory data,etc.),and the included patients were classified according to TCM syndrome differentiation.Abdominal aortic calcification(AAC)was diagnosed by lateral abdominal X-ray.According to whether or not AAC was detected,the patients were divided into calcification group and non-calcification group,and the differences in age,gender,body mass index(BMI),past history,TCM syndrome type and biochemical indicators were compared between the two groups.The independent sample T test was used for the qu antitative data,and the chi-square test or Fisher’s exact prob ability method was used to compare the rates of gender,Basic diseases and TCM syndrome type.At the same time,combined with the clinical differences between the two groups,binary logistic regression analysis was conducted to explore the risk factors of abdominal aortic calcification in CKD3-5 patients.Results:1.A total of 96 non-dialysis patients with CKD3-5 were enro lled,including 53 males and 43 females.CKD3 stage 50 cases,CK D4 stage 29 cases,CKD5 stage 17 cases.There were 45 cases in calcification group and 51 cases in non-calcification group.2.The age(P<0.001)in the calcification group were higher than those in the non-calcification group.There were no statistically significant differences in gender,BMI,smoking history,CKD stage,primary glomerulonephritis,hypertension,diabetes and other basic diseases between the two groups(P>0.05).3.The levels of serum phosphorus(P=0.001),parathyroid hor mone(P=0.026)and calcium phosphorus product(P=0.001)in the calcified group were significantly higher than those in the non-calcified group,and the levels of serum albumin(P<0.001)were lower than those in the non-calcified group,with statistically significant differences.There were no statistically signific ant differences in hemoglobin,total cholesterol,triglyceride,LDL,estimated glomerular filtration rate,blood calcium,alka line phosphatase and other biochemical indicators between the two groups(P>0.05).4.In the calcification group,the patients with spleen-kidney Yang deficiency syndrome and stasis-turbidity syndrome were significantly more than those in the non-calcification group.The non-calcification group had significantly more patients with spleen-kidney qi deficiency syndrome and water-dampness syndrome than the calcification group,with statistically significant differences(P<0.05).Meanwhile,in the calcification group,the spleen-kidney Yang deficiency syndrome and the stasis-turbidity syndrome were the most common of all.In the non-calcificatio n group,the spleen-kidney Qi deficiency syndrome and the water-dampness syndrome were the most common of all.5.Age,blood phosphorus,spleen-kidney Yang deficiency synd rome,and stasis syndrome were independent risk factors for abd ominal aortic calcification in CKD3-5 non-dialysis patients(O R>1,P<0.05),and serum albumin was a protective factor for abdominal aortic calcification in CKD3-5 non-dialysis patients(OR<1,P<0.05).Conclusion:1.In this study,the prevalence of abdominal aortic calcifi cation in non-dialysis patients with CKD3-5 was 46.88%.Age and blood phosphorus were independent risk factors for abdominal aortic calcification,and serum albumin was a protective factor for abdominal aortic calcification.2.Abdominal aortic calcification in non-dialysis patients with CKD3-5 is closely related to spleen-and-kidney Yang deficie ncy syndrome and stasis-turbidity syndrome,which are also independent risk factors for abdominal aortic calcification. |
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