A Preliminary Study On The Regulation Of Cerebral Blood Flow In Patients With Post-Stroke Depression

Objective: 1.Transcranial Doppler ultrasound(TCD)was used to study the function of cerebral blood flow regulation in patients with post-stroke depression.2.To explore the relationship between post-stroke depression and cerebral blood flow regulation.Methods: 1.30 cases of acute unilateral cerebral infarction with post-stroke depression in the second Department of Neurology of Dalian Central Hospital were selected as the study group,and 30 cases of age and gender matched acute unilateral cerebral infarction without post-stroke depression as the control group.2.The general data of the two groups were collected: age,gender,drinking history,smoking history,hypertension history,diabetes history,total cholesterol,triglyceride,low-density lipoprotein,high-density lipoprotein,homocysteine,carotid intimal thickness,nhiss score,Essen score.3.TCD lying and standing test,breath holding test and breath exchange test were performed in both groups.The frequency of "W" wave,slope of "W" wave,difference of cerebral blood flow velocity in lying and standing position,breath holding index,change rate of PI and RI before and after breath holding,change rate of cerebral blood flow velocity before and after breath changing,PI and RI before and after breath changing,lying position blood pressure difference,lying position heart rate difference were calculated.The rate of change was used to evaluate the function of cerebral blood flow regulation in patients with post-stroke depression.4.To explore therelationship between the degree of post-stroke depression and the function of cerebral blood flow regulation by linear regression analysis of the depression score(HAMD-17score)and the index of cerebral blood flow regulation.Results: 1.There was no statistical difference in the general data of the two groups.2.The slope of "W" wave and the frequency of "W" wave in the study group were lower than those in the control group,and the difference of cerebral blood flow velocity in the study group was higher than that in the control group.3.The change rate of breath holding index,PI and RI before and after breath holding,cerebral blood flow velocity before and after breath holding,PI and RI before and after breath holding were lower in the study group than in the control group.4.The depression score of the study group was inversely proportional to the slope of "W" wave in supine and upright position,and positively proportional to the difference of cerebral blood flow velocity in supine and upright position.5.The depression score of the study group was inversely proportional to the breath holding index,the change rate of PI and RI before and after breath holding,the change rate of cerebral blood flow velocity before and after breath holding,and the change rate of PI and RI before and after breath holding.Conclusions: 1.The function of cerebral blood flow regulation is impaired in patients with post-stroke depression.2.The more serious the degree of post-stroke depression is,the more serious the impairment of cerebral blood flow regulation function is.3.Impaired cerebral blood flow regulation may be one of the potential mechanisms of poor prognosis in patients with post-stroke depression.