Clinical Characteristics Of Mycoplasma Pneumoniae In Hospitalized Children In Xuzhou Area

Part one Epidemic characteristics of mycoplasma pneumoniae in hospitalized children in Xuzhou region from 2013 to 2018Objective:The epidemic characteristics of mycoplasma pneumoniae in children in Xuzhou region from 2013 to 2018 were analyzed to provide theoretical basis for clinical diagnosis and treatment.Methods:From January 2013 to December 2018,16793 children with respiratory tract infection in Xuzhou Children's Hospital were selected as research objects to analyze the overall situation of respiratory tract infection pathogens from 2013 to 2018 as well as the detection rate of MP in different ages,genders,seasons,and respiratory tract diseases.Results:The etiological examination of the 16793 children with respiratory tract infection were carried out,the detection rates of mycoplasma pneumoniae,virus,and bacteria were 31.0%(5200/16793),33.1%(5559/16793)and 22.4%(3762/16793)respectively,among which 2046(12.2%)were mixed infection.The positive rates of MP were 15.1%(1214/8017),40.3%(2452/6079)and 56.9%(1534/2697)in infant group,preschool group and school group respectively,the difference was statistically significant(?2=2035.700,P<0.001).MP can be detected throughout the year,the total incidence rate of four seasons is 17.6%(796/4532)in spring,58%(2506/4518)in summer,30.9%(1118/3614)in autumn and 18%(780/4329)in winter,respectively,with the highest incidence rate in summer and lowest in spring(?2=2200.500,P<0.001).Among 16793 children,5200 cases of MP were detected,including 2022 cases of boys(27.2%),3178 cases of girls(33.3%),with more females than males,the difference was statistically significant(?2=55.586,P<0.001).From 2013 to 2018,the detection peak of MP was in July(67.7%),and the lowest detection rate was in January(9.4%),the difference was statistically significant(?2=2514.900,P<0.001).From 2013 to 2018,the detection rates of MP were 28.4%,32.8%,29.0%,30.1%,30.7%and 34.1%respectively,with statistical significance(?2=33.050,P<0.001).There was no significant difference in the detection rate of MP in the same month from 2013 to 2018(P>0.05).The positive rate of MP was 80.0%(650/813)in lobar pneumonia,70.0%(348/497)in interstitial pneumonia,34.7%(192/553)in bronchitis,27.7%(69/249)in bronchiolitis,27.2%(1014/3734)in upper respiratory tract infection,and 26.9%(2927/10947)in bronchiolitis,the differences were statistically significant(?2=1389.000,P<0.001).Conclusions:1)From 2013 to 2018,the positive rate of MP detection in Xuzhou was 31%,and MP could be prevalent around the year.Summer has the highest incidence rate,while the spring has the lowest incidence rate.The highest detection rate was in July,while the lowest was in January;2)MP infection could be found in children of all ages,the infection rate of school-age children is the highest,with more females than males.3)MP could be detected in a variety of respiratory infectious diseases,but the highest detection rate was in lobar pneumonia.Part two Clinical characteristics of mycoplasma pneumoniae in hospitalized children in Xuzhou areaObjective:This paper analyzed the clinical characteristics of mycoplasma pneumoniae in hospitalized children in Xuzhou,and further understood the epidemiological characteristics of mycoplasma pneumoniae in children in Xuzhou,so as to provide theoretical basis for clinical treatment.Methods:The clinical features of MPP in 3925 children from January 2013 to December 2018 in Xuzhou were selected as the observation group.Results:1)The occurrence rate of clinical symptoms of wheezing and dyspnea were significantly higher in the infant group than those in the preschool group and the school age group,and the occurrence rate of moist rales in the school age group were lower than those in the infant group and the preschool group,while the occurrence rate of cough in each age group has no differences(P>0.05);2)The fever time in the school age group was significantly longer than that in the preschool group and the infant group(F=9.527,P=0.007),and with the increase of age,the peak of fever increased gradually(?2=8.439,P=0.005);3)The white blood cell in the preschool and school age group were lower than those in infant group(F=4.195,P<0.05),C-reaction protein(CRP)in preschool group and school age group were higher than that in infant group(F=8.335,P<0.05),while the results of the laboratory examination about ESR and HB showed no statistical difference;4)The pulmonary imaging manifestations of MPP children:the patchy shadows of children in school-age group were lower than that in infant group and preschool group,while the leaf/segment shadows and pleural effusion were higher than those in the other two groups(P<0.001),while the pulmonary interstitial lesions showed no statistical difference in all age groups.5)The incidence of skin rash in school age group was higher than that in infant group and preschool group(?2=46.051,P<0.001),and there was no statistical differences in extrapulmonary injuries of digestive system,circulatory system,and urinary system;6)There was no statistical difference in clinical treatment effect of MPP children between infant group,preschool group,and school age group(P>0.05);7)No statistical difference was found in mixed infection of MPP children between infant group,preschool group,and school age group(P>0.05).Conclusions:1)The most common clinical manifestations of MPP are fever and cough.The infant group is more prone to panting and dyspnea,and may involve multiple systems outside the lung.2)The imaging manifestations of MPP children were mainly patchy shadows in the infant group,leaf/segment shadows and pleural effusion in the school-age group.