The Relationship Between Different Adjuvant Treatment And Prognosis Of 350 Cases ?B-?A Cervical Squamous Cell Carcinoma Patients With Intermediate Risk Factors After Radical Resection

Objective:To explore the relationship between adjuvant therapy and prognosis in patients with early cervical cancerMethods:This study retrospectively analyzed patients with cervical squamous cell carcinoma of stage FIGO IB-? A who underwent radical hysterectomy and pelvic lymph node dissection for the first time in Yun nan provincial cancer hospital from January 1,2013 to December 31,2015.At the same time,We conducted univariate and multivariate analyses of different clinicopathological factors to further clarify whether patients with moderate risk after early cervical cancer need adjuvant therapy and which adjuvant therapy has a better prognosis.Results:1.The 5-year progression-free survival rate was 93.2%in the one risk factor group and 86.3%in the two risk factor groups(P=0.024).The 5-year overall survival rate was 93.3%in the one risk factor group and 91.0%in the two or more risk factors groups.There was no statistical significance between the two groups(P=0.274).2.For patients with one risk factor,the 5-year disease-free survival rate was 91.3%in the group without adjuvant treatment,and 93.8%in the group with adjuvant treatment.The comparison between the two groups was not statistically significant(P=0.391).The 5-year overall survival rate was 89.4%in the group without adjuvant treatment and 94.3%in the group with adjuvant treatment(P=0.284).3.Among the patients with two or more risk factors,the 5-year disease-free survival rate was 74.8%in the group without adjuvant treatment and 91.1%in the group with adjuvant treatment.The comparison between the two groups was statistically significant(P=0.02).The 5-year overall survival rate was 86.5%in the group without adjuvant treatment and 92.8%in the group with adjuvant treatment(P=0.201).4.In the group with two or more risk factors,the 5-year disease-free survival rate was 77.8%in the chemotherapy group,79.5%in the radiotherapy group,and 94.4%in the concurrent chemoradiotherapy group,with no statistically significant difference(P=0.499).The 5-year disease-free survival rate was 93.8%in the 2D radiotherapy group,91.1%in the 3D conformation group,and 90.0%in the Intensity Modulated Radiotherapy group,with no statistically significant difference(P=0.893).The 5-year disease-free survival rate was 92.9%in the brachytherapy group and 91.3%in the no brachytherapy group,and the comparison between the two groups was not statistically significant(P=0.751).Conclusion(s):1.Patients with 1 risk factor after Radical resection of early cervical cancer were superior to those with 2 or more risk factors in 5-year PFS and 5-year OS.2.Postoperative adjuvant therapy could not improve the prognosis of patients with 1 risk factor.3.Postoperative adjuvant therapy for patients with more than 2 risk factors improved the 5-year disease-free survival,but not the OS.4.There was no statistical difference between the three adjuvant treatment methods of Adjuvant Chemotherapy,Radiotherapy and Concurrent Chemoradiotherapy.5.There was no statistical difference in the prognosis of Two-dimensional Treatment,Three-dimensional Conformal Radiotherapy and Intensity-Modulated Radiation Therapy,The Brachytherapy did not improve the prognosis.