| Objective: To explore the clinical efficacy of shenqizhilong decoction for idiopathic membranous nephropathy with Qi stagnation and blood stasis pattern.Methods: We conducted a single-center randomized,single-blind control study using the 2016-2017 patients diagnosed with idiopathic membranous nephropathy.They were randomly divided and assigned to three groups,and each group consisted with 42 participants.The levels of serum albumin,24-hour urinary protein quantity,urea nitrogen,serum creatinine,triglyceride and total cholesterol before and after treatment were measured by automatic biochemical analyzer.TCM syndrome was assessed by TCM-syndrome scale.All data statistical analyses were performed by SPSS 17.0,and statistical charts were conducted by Graphpad7.0 software.Statistical significance of the differences among continuous variables was tested with t tests or ANOVA,and Chi-square tests for categorical variables.Results:(1)There were no significant differences in serum albumin levels,24-hour urinary protein quantity,urea nitrogen,blood creatinine,triglycerides,and total cholesterol levels among the three groups after treatment(P>0.05).The protein level was significantly higher than before treatment(P <0.05);there was no significant difference in serum albumin level between group A and group B after treatment(P> 0.05);the serum albumin level after treatment in group C was significantly higher than that of A,Group B(P <0.05).The 24 h urinary protein quantification in the three groups after treatment was significantly lower than before treatment(P <0.05);the 24 h urinary protein quantification in group A was not significantly different from that in group B(P> 0.05);the C urinary protein quantification in group C was 24 h after treatment.Significantly lower than those in groups A and B(P<0.05);there was no significant difference in urea nitrogen levels and serum creatinine between the three groups after treatment(P>0.05);triglyceride levels in the three groups were significantly lower than before treatment(P<0.05);There was no significant difference in triglyceride levels between group A and group B after treatment(P>0.05);triglyceride levels in group C were significantly lower than those in groups A and B after treatment(P<0.05);After treatment,the total cholesterol level in the three groups was significantly lower than before treatment(P<0.05),but there was no significant difference between the groups A and B after treatment(P<0.05);the total cholesterol level in group C was significantly higher than that in groups A and B after treatment.Decrease(P <0.05).(2): There was no significant difference in TCM syndrome scores before treatment in the 3 groups(P>0.05);TCM syndrome scores in the 3 groups after treatment were significantly lower than before treatment(P<0.05);TCM syndromes in the group A after treatment There was no significant difference in waiting scores between group B and group B(P>0.05).The TCM syndrome scores of group C were significantly lower than those of groups A and B after treatment(P<0.05).The total effective rate of membranous nephropathy patients after treatment was 95.23%(40/42),which was significantly higher than that of group A.76.19%(32/42)and group B.73.81%(31/42).The difference was statistically significant(P<0.05).In group A,patients with idiopathic membranous nephropathy of qi deficiency and blood stasis type had gastrointestinal ulcers after treatment,2 cases of elevated blood glucose,3 cases of hypertension,1 case of infection,5 cases of insomnia and irritability,and 2 cases of Cushing-like syndrome;After treatment,side effects occurred in 1 case of peptic ulcer,2 cases of elevated blood sugar,3 cases of hypertension,2 cases of infection,6 cases of insomnia,irritability,and 2 cases of Cushing-like syndrome;2 cases of side effects occurred in 2 cases of elevated blood sugar,hypertension There were 3 cases,1 case of infection,4 cases of insomnia and irritability,and 1 case of Cushing-like syndrome.There was no significant difference in the incidence of side effects among the three groups(P>0.05).Conclusions: 1.Shenqizhilong decoction has a significant efficacy for idiopathic membranous nephropathy with Qi stagnation and blood stasis pattern,and the combination with tacrolimus is better than tacrolimus or shenqizhilong decoction alone,which has the characteristics of slight side effect and high medication safety;2.Shenqizhilong decoction may improve lipid metabolism and serum albumin levels,and reduce proteinuria among patients with idiopathic membranous nephropathy with Qi stagnation and blood stasis pattern. |
PDF Full Text Request