Quadratus Lumborum Block-propofol Anesthesia On Serum Angiogenesis Related Factors In Patients Undergoing Surgery For Colorectal Cancer

[Objectives]whether QLB-propofol anesthesia versus sevoflurane-sufentanil anesthesia can reduce the concentration of angiogenesis-related factors and their impact on patients’ postoperative outcomes lacks firm clinical evidence.Therefore,two different anesthetic methods were selected to narcotize patients with open sphincter sparing operation.Changes of angiogenesis-related factors during the perioperative period were analyzed.It is of great significance to search for the optimum anesthesia management for patients with colorectal cancers.[Materials and Methods]Sixty patients were randomly allocated to receive sevoflurane-sufentanil anesthesia(group G)and QLB-propofol anesthesia(group Q)in 60 mL ropivacaine 0.33%for 48 hours.The intraoperative hemodynamic changes was tested during operation.The opioid consumption was evaluated perioperatively.Postoperative recovery was also assessed.Serum levels of VEGF-C and TGF-β1 concentrations were measured perioperatively.[Results]There was no significant difference in hemodynamic changes between two groups(P<0.05).MAP and HR both were lower in the group Q than in group G 3min after incision(T3)and 3min after celiac exploration(T5)(P<0.05).There was also no statistically difference in RVAS and DVAS between two groups(P>0.05).The time to first analgesic request,time to recovery of intestinal function,and leaving bed in group Q was significantly shorter than group G(P<0.05).Group Q showed decreases in VEGF-C and TGF-β1 24 hours after surgery compared with group G(P<0.05)[Conclusions]QLB-propofol anesthesia blunts consumption of opioids to an extent comparable to sevoflurane-sufentanil anesthesia without compromising hemodynamic stability.In addition,QLB-propofol anesthesia is also beneficial to the early outcome of patients after the operation.QLB-anesthesia can reduces serum concentrations of angiogenesis related factors during open sphincter sparing operation.This result is consistent with the hypothesis that anesthesia techniques may affect the long-term prognosis of colorectal cancer.