MicroRNA-320b Suppressed The Progression Of Papillary Thyroid Carcinoma Via Targeting ARPP19

Objective:MicroRNAs play an important regulatory role in the development of many cancers,and thyroid papillary carcinoma is no exception.Although clinical practice studies have confirmed that MiR-320b can effectively inhibit the further development of a variety of tumors,its mechanism of action on papillary thyroid carcinoma remains a mystery.Therefore,in this research,the author conducted targeted research and research to fully understand and master the effect of miR-320b on papillary thyroid carcinoma and its mechanism of action.Methods:The professional and advanced RT-PCR technology was used to detect the expression level of MiR-320b in different tissues.The target gene that binds to miR-320b is inferred using a dual luciferase report that is currently highly regarded and recognized by the industry.Thus,a series of in vitro cell function tests can be used to detect the effect of miR-320b on thyroid papillary carcinoma cells.Results:The expression level of miR-320b continued to decrease.Overexpression of miR-320b significantly attenuated the reproductive capacity of 8505C cells and accelerated cell death compared to the control group.However,once the interference with miR-320b is increased,HH-4 cells will rapidly develop and delay cell death.In the experiments carried out,the combination of MiR-320b and ARPP19 revealed that the ability of tumor cells to develop was significantly weakened.Thus,overexpression of miR-320b can delay cell growth and accelerate the overexpression of overexpressed ARPP19,but interfere with miR-320b to enhance cell proliferation and inhibit ARPP19 suppression.Conclusion:The combination of miR-320b and ARPP19 can effectively inhibit the further development of thyroid papillary carcinoma cells,which provides a strong basis for the medical community to treat the disease.