| Objective:The clinical manifestations,EEG features and treatment outcome of children with benign epilepsy with centro-temporal spikes were analyzed.Methods:Selected from January 2016 to January 2020 in the fourth affiliated hospital of kunming medical university and neurology clinic diagnosis of the clinical data of 43 cases of BECT,combining with the video EEG monitoring data,analysis of the patient's clinical seizure type,electroencephalogram features,cognitive function,the efficacy of drug treatment and the change of electroencephalogram after treatment.Results:1.Among the 43 children with BECT,there were 24 males and 19 females The average age of onset was 7.67±2.49 years old,and the age of 81.4%was 5 to 10 years old.2.The clinical seizures of 43 children were related to the decrease of sleep or arousal,62.7%of the children had seizures within 1 hour after falling asleep,69.8%of the children had partial motor seizures,33.3%had generalized tonic-clonic seizures,and 67.44%of the children had seizures lasting 1-5 minutes.The seizure frequency was 1 to 12 times per year,with an average of(2.32 ± 1.85)times per year,and the attack frequency was mainly concentrated in 1 to 3 times per year.3.In 43 cases,10 cases(23.26%)and 33 cases(76.74%)were treated with bilateral VEEG discharge.Among the unilateral discharges,there were 17 cases(39.53%)in the left Rolandic area and 16 cases(37.21%)in the right Rolandic area.4.Cognitive function:Among the 10 children with Wechler's Intelligence scale for Children,FIQ did not have mental deficiency or lower than normal.However,in terms of verbal IQ and operational IQ,all the 10 children with BECT had uneven development.5.The follow-up time ranged from 3 months to 4 years,and 40 cases were treated with single AEDs orally and 3 cases were treated with combined AEDs.In LEV group,17 cases(50.0%)were completely controlled and 17 cases(50.0%)were effective.In the VPA group,2 cases(40.0%)were completely controlled and 3 cases(60%)were not.In LEV group,there were 34 children,31 cases showed improvement in EEG,and 3 cases showed no significant change in EEG.In the VPA group,there were 5 cases,2 cases showed improved EEG,and 3 cases showed poor clinical seizure control and no changes in EEG.Clinical seizure control was effective in CBZ group,and eeg was improved.In the combined treatment group,3 patients had complete control of clinical seizures,but no significant changes in EEG.Among them,1 case has learning difficulty and slow reaction time.Conclusion(s):1.BECT is highly age-dependent,and the onset is closely related to the decrease of sleep and awakening degree.The onset type is mainly partial motor onset,and the discharge in Rolandic region can be seen in EEG.The typical BECT antiepileptic therapy has ideal therapeutic effect and good prognosis.2.BECT children treatment should be individualized,and the selection of antiepileptic drugs should be integrated with the clinical manifestations,EEG characteristics and therapeutic efficacy of the children to evaluate rational drug use.3.BECT children exist cognitive dysfunction,partly in positive control of its clinical epilepsy attack at the same time,should use the appropriate measurement tools and methods,the early detection of cognitive impairment,and analyze the factors lead to the cognitive impairment,intervention and individualized treatment as soon as possible,so as to improve the patient's cognitive function,improve the quality of their learning and life. |
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