Clinical Observation Of Noncoronary Cardiac Abnormalities In Chinese Children With Kawasaki Disease

Objective Kawasaki disease(KD)is an acute,self-limited vasculitis.Coronary artery aneurysms(CAA)serve as a major contributor to the long-term prognosis of KD.In addition,acute KD usually also leads to several kinds of noncoronary cardiac abnormalities(NCA)involving the pericardium,myocardium and endocardium.The objectives of present study were to analyze the incidence,manifestations and outcomes of NCA in Chinese children with KD.Methods142 Chinese children with KD were recruited from July 2015 to April 2018.Blood samples were collected at 24 h pre-Intravenous immunoglobulin(IVIG)therapy.Several inflammatory mediators and biomarkers for acute myocardial infarction were detected.Echocardiography(ECG)and electrocardiography were performed.Results Plasma white blood cells counts(WBC)was significantly increased in patients with IVIG-nonresponsive KD when compared with their IVIG-responsive counterparts.A total of 106 children(74.65%)suffered from NCA,including 8 patients(5.63%)with pericardial effusion,23 patients(16.20%)with acute myocarditis,101 patients(71.13%)with valvular regurgitation,and 8 patients(5.63%)with abnormal ECG.No significant differences were observed in the distribution of clinical classification and the response to IVIG therapy regardless of NCA exhibited or not.Conclusion NCA is almost universal in acute KD and mainly manifests as valvular regurgitation.However,it has no influence on clinical classification and the response to IVIG therapy.