Clinical Study Of Anti-Ro52 Antibody And Connective Tissue Disease-related Interstitial Lung Disease

Objective:Connective tissue disease is a chronic autoimmune disease that can cause damage to multiple organs such as skin,joints,muscles,heart and lungs.Lungs are the organs most commonly affected by connective tissue disease,and interstitial lung disease is the most common manifestation.Anti-Ro52 antibody is one of the most common anti-nuclear antibodies currently known and can be found in a variety of autoimmune diseases.The purpose of this study was to evaluate the value of anti-Ro52 antibodies as autoantibodies in the diagnosis of CTD-ILD.Methods: A retrospective analysis of 281 patients admitted to our department of rheumatology and immunology from 2015 to 2018 with a clear diagnosis of primary sjogren's syndrome,polymyositis / dermatomyositis,rheumatoid arthritis,and systemic sclerosis.Basic data,HRCT,complement,erythrocyte sedimentation rate,immunoglobulin and other test indicators were used to analyze the interstitial changes in the lungs of patients,and the correlation analysis between anti-Ro52 antibody and interstitial lung disease was performed.Results:281 patients with connective tissue disease were included and divided into positive and negative groups according to the anti-Ro52 antibody results.There was no statistical difference in age and gender between the two groups(P> 0.05).The anti-Ro52 antibody positive group had significantly higher Ig G than the negative group.In patients,complement C3 was significantly lower than that in the negative group,and the difference was statistically significant(P <0.05).In patients with primary Sjogren's syndrome and polymyositis / dermatomyositis,the incidence of ILD in the anti-Ro52 antibody positive group was significantly higher than that in the negative group.Correlation analysis was performed in the two groups.The difference between the two groups was statistically significant(P <0.05).Conclusion: Anti-Ro52 antibodies are a risk factor for ILD in patients with primary Sjogren's syndrome and polymyositis/dermatomyositis.In patients with primary Sjogren's syndrome and polymyositis/dermatomyositis,if anti-Ro52 antibody is positive,the occurrence of ILD should be highly vigilant,lung function should be screened,and HRCT should be performed if necessary.The activation of autoimmunity plays an important role in the pathogenesis of ILD.