Study On The Diagnostic Value Of N-pentapolymerin-3 And TyG Index In Children With Non-alcoholic Fatty Liver Disease

Objective:To measure the level of pentraxin-3(PTX-3)of NAFLD children and healthy children by Enzyme-Linked Immuno Sorbent Assay(ELISA),and to analyze the relationship of serum transaminase and PTX-3 in order to explore the diagnostic value of PTX-3 in children with NAFLD.Besides,the Ty G index was calculated in order to explore the diagnostic value of PTX-3 and Ty G index in children with NAFLD.Methods:From July 2017 to December 2019,64 children with Non-alcoholic fatty liver disease(NAFLD)diagnosed by imaging were selected from the outpatient of pediatric digestive department of Shengjing Hospital of China Medical University,17 healthy children were selected as the PTX-3 control group,and 18 healthy children were selected as the Ty G control group.The height,weight,BMI of children with NAFLD were measured.ALT,AST,GGT,uric acid,TG,TC,HDL-C,LDL-C,Apo-A1,Apo-B,FPG,FINS and other biomarkers were detected,and to calculate HOMA-IR and Ty G.Besides,the plasma PTX-3 levels of NAFLD children and the PTX-3 control group were measured by ELISA and compared.The levels of serum fasting blood glucose and triglyceride in the Ty G control group were measured and compared with those in children with NAFLD.Results:1 There was no significant difference in gender and age between the NAFLD and the control group(P>0.05).2 PTX-3 level in NAFLD children[2.24(1.42,4.19)ng/m L] was higher than that in the control group[1.57(0.84,2.26)ng/m L],with a statistically significant difference(Z=-2.604,P=0.009).3 The Ty G index of NAFLD children(0.92±0.24)was higher than that of the control group(0.62±0.25),with a statistically significant difference(t=4.628,P<0.001).4 There was no correlation between PTX-3 and BMI,ALT,AST,GGT,triglyceride,total cholesterol,HDL-C,LDL-C,Apo-A1,Apo-B,fasting insulin,fasting blood glucose,HOMA-IR and uric acid(P>0.05).5 The Ty G index was related to ALT,GGT,uric acid,triglyceride,total cholesterol,LDL-C,Apo-B,fasting blood glucose,fasting insulin,HOMA-IR(P<0.05),but had no correlation with BMI,AST,HDL-C,Apo-A1(P>0.05).Conclusion:PTX-3 can be helpful to diagnose NAFLD in children.Ty G index may contributed to assess the risk of NAFLD in children,and may reflect liver cell injury to a certain extent.