The Study Of Response Surface Models Establishment And Comparison For Anesthesiology Pharmacodynamics Interaction

At present,two or more drugs are used for anesthesia during surgery.There are complex interactions between drugs.In order to provide more effective guidance for clinical administration,the response surface model methods are often used to describe the pharmacodynamic interactions of two anesthetic drugs more comprehensively.However,multiple response surface models have different characteristics.Selecting different models to describe different drugs and drug effects will have different results,so the comparative study of response surface models and the selection of the best fit model can better describe the drug interactions.In the first part of this study,we compared the response surface models with the existing research data,and selected five commonly used response surface models: Full Greco,Minto,reduced Greco,Scaled C50 Hierarchy,and Fixed C50 Hierarchy.The four pharmacodynamics during the esophageal instrumentation were fitted and the best fitting models were selected respectively,so that the conclusion that the model comparison study can provide clinical significance is concluded.In the second part of this study,two types of pharmacodynamic effects of dexmedetomidine combined with propofol during gastroscopy were studied.The five response surface models were also used.Therefore,the reduced Greco model which can be better described loss of response during the operation,and reduced Greco,Full Greco can better describe the body movements during enteroscopy and the total period of gastrointestinal.Through a comparative study of the two parts,we find that the response surface model can fit the efficacy of anesthetic drugs well and can accurately show the interaction of different anesthetic drugs.At the same time,the optimal fitting model selected through the comparison of different models can provide certain guidance for clinical administration.