The Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome And Vestibular Function Was Evaluated By Vestibular Evoked Myogenic Potential

Objective:Obstructive sleep apnea hypopnea syndrome(OSAHS)patients and control group volunteers were monitored for vestibular evoked myogenic potential(VEMP)to study Relationship between obstructive sleep apnea hypopnea syndrome and vestibular function.Methods:Randomly selected 68 patients with OSAHS who met the inclusion criteria as the research subjects.Inclusion criteria for 68 patients with OSAHS:Patients diagnosed with OSAHS according to the Guidelines for the Diagnosis and Treatment of Obstructive Sleep Apnea Hypopnea Syndrome(2011 Revision).The OSAHS division criteria are: Mild: 5?AHI?15,85% ?Sa O2?90%;Moderate: 15 <AHI?30,80% ?Sa O2 <85%;Severe: AHI> 30,Sa O2 <80%.49 volunteers have been seleched whose test result of otoacoustic emission and pure tone audiometry are normal with no hearing loss,no tinnitus,no dizziness,no history of noise exposure.VEMP was monitored by 68 OSAHS patients and 49 volunteers who matched the inclusion criteria to compare the indicators between the two groups.Because the obtained results do not conform to the normal distribution,the monitoring results were analyzed by rank sum test.Results:1.The cervical vestibular evoked myogenic potential's extraction rate of patients in the OSAHS group was lower than that in the control group.The P values of P1 latency,interwave period,amplitude,and binaural asymmetry ratio were 0.000,0.001,0.000,and 0.003,(P<0.05).The differences were statistically significant.The P1 latency and binaural asymmetry ratio in the experimental group were larger than those in the control group,and the amplitude and interwave period were smaller than in the control group.The latency of N1 was P = 0.211(P>0.05),and the difference was not statistically significant.2.The ocular vestibular evoked myogenic potential's extraction rate of patients in the OSAHS group was lower than that in the control group.The P values of the P1 latency,N1 latency,amplitude,and binaural asymmetry ratio were 0.010,0.003,0.019,0.000(P<0.05).The differences were statistically significant.The P1 latency,the N1 latency and binaural asymmetry ratio in the experimental group were larger than those in the control group,the amplitude was smaller than in the control group.The interwave period was P=0.844(P>0.05),and the difference was not statistically significant.3.The left and right ears of the experimental group were compared,the results showed that the latency of P1,the latency of N1,the interwave period,and the amplitude of cVEMP and oVEMP were not statistically significant(P>0.05).4.The results of statistical analysis of cVEMP and oVEMP in patients with mild,moderate and severe OSAHS showed that The P values of binaural asymmetry ratio of cVEMP and the amplitude of oVEMP were 0.045,0.019(P<0.05).The differences were statistically significant.Binaural asymmetry ratio of cVEMP and the amplitude of oVEMP of patients with mild,moderate were larger than those in severe OSAHS.The results of the rest of the indicators were not different.Statistical significance(P>0.05).Conclusion:The comparison between the OSAHS group and the control group found that extraction rate of cVEMP was lower,the latency of P1 of cVEMP was prolonged,binaural asymmetry ratio of cVEMP was significantly larger than that of the control group,the amplitude and interwave period of cVEMP were shortened;The latency of P1 and N1 of oVEMP is prolonged,extraction rate of oVEMP was lower,the asymmetry ratio binaural asymmetry ratio of oVEMP is increased,and the amplitude of oVEMP is reduced.This study suggests that OSAHS can cause dysfunction of vestibule.