The Clinical Value Of Neutrophil To Lymphocyte Ratio,Neutrophil To Platelet Agglutination Ratio And D-dimer In Evaluating The Activity Of Ulcerative Colitis

Objective: To analyze the relationship between the activity of UC and the ratio of neutrophils to lymphocytes(NLR),the ratio of neutrophils to platelets(NPR)and the level of D-dimer.Methods: from January 2016 to June 2019,205 UC patients were selected from the Department of Gastroenterology,Shengjing Hospital Affiliated to China Medical University,including 117 patients in active period and 88 patients in remission period.The levels of NLR,NPR and D-dimer in the two groups were analyzed,and the relationship between them and the severity of UC was evaluated.The specificity,sensitivity and cut off value of the evaluation for the diagnosis of UC in active period were evaluated.Results: compared with the remission stage,the levels of NLR,NPR and D-dimer in the active stage were significantly higher than those in the remission stage(P < 0.05).The area under the ROC curve for the diagnosis of UC in the active stage was 0.815,0.729 and 0.898,respectively.The sensitivity,specificity and cut-off values were NLR(SEN: 75.2%,SPE: 81.6%,cut-off value: 2.07);NPR(SEN: 70.9%,SPE: 72.0%,cut-off value: 15.49);D-dimer Body(SEN: 76.9%,SPE: 88.6%,cut off value: 126.5).With the increase of UC activity,NLR,NPR,D-dimer were positively correlated with mild,moderate and severe activities.Conclusion: NLR,NPR,D-dimer have important clinical value in the diagnosis of active stage of ulcerative colitis and the evaluation of disease activity...