The Value Of Fecal Calprotectin In The Evaluation Of The Disease Activity Of Ulcerative Colitis

Background:Clinically,Mayo score and invasive colonoscopy are important methods for assessing the severity of ulcerative colitis(UC)patients.This article aims to investigate the advantages of non-invasive index fecal calprotectin(FC)in determining the degree of clinical and microscopic disease activity in UC,and to analyze the correlation between FC and Mayo score and endoscopic index of severity(UCEIS).Methods:A retrospective analysis of 100 cases of UC patients diagnosed by endoscopy and histopathology in the second digestive department of Sheng Jing Hospital affiliated to China Medical University from March 20 to June 2019,scored ? 2 points for Mayo and no single score >1 was divided into clinical remission group,and the Mayo score3-12 was divided into clinical activity group.The UCEIS 0-1 is divided into the microscopic remission group,and the UCEIS 2-8 is divided into the microscopic activity group.The ROC curve was used to analyze FC and the blood-related inflammation indexes(WBC,PLT,HB,etc.)and to predict the clinical and microscopic severity.The correlation between each index and the Mayo score and UCEIS was compared.Results : The values of FC,WBC,PLT,CRP and ESR in the Mayo score were significantly higher than those in the clinical remission group.The HB and ALB values were significantly lower than those in the clinical remission group.The values of FC,WBC,PLT,CRP and ESR in the active group were significantly higher than those in the microscopic remission group.The HB and ALB values were significantly lower than those in the microscopic remission group,and the difference was significant(p<0.01).FC,WBC,PLT,CRP and ESR were positively correlated with clinical severity and endoscopic performance.HB and ALB levels were negatively correlated with clinical severity and endoscopic performance,and the correlation coefficient of FC was the highest,r=0.899 and r=0.528 respectively.FC>45.90 ?g/g can accurately diagnose the clinical activity period of UC.The sensitivity,specificity,positive and negative predictive value were 95.31%,97.22%,97.35% and 95.04% respectively.FC>39.17 ?g/g can accurately diagnose the active period of UC microscopy.The sensitivity,specificity,positive and negative predictive value were 81.93%,94.12%,96.22% and 74.06%respectively.Conclusion:FC is a reliable non-invasive indicator that can evaluate the clinical and microscopic disease activity of UC patients.