Relation Of Neutrophil-to-lymphocyte Ratio To Acute Kidney Injury In Patients With Acute Pancreatitis Complicated Infection

Objective:The local or systemic infections often may be secondary to acute pancreatitis,constituting the second largest death peak.When patients with secondary infection are complicated by organ failure at the same time,the mortality rate can reach 35.2% and kidney and lung are the most common organs.When acute pancreatitis progresses to severe,about 70%-80% of deaths are caused by acute kidney injury and acute lung injury.To investigate whether the neutrophil-to-lymphocyte ratio(NLR)as an indicator of systemic inflammatory status can predict the occurrence of acute kidney injury in patients with acute pancreatitis complicated infection.Methods:The study retrospectively analyzed the case data of 93 patients with acute pancreatitis complicated by infection treated at the Emergency,Gastroenterology,and Surgery of Hebei Medical University Second Hospital from September 2017 to December 2019.The NLR,bedside index for severity in acute pancreatitis,and quick sequential organ failure assessment scores were calculated.The primary study endpoint was organ failure and the secondary study endpoint was 28-day mortality.Statistical analysis and mapping using SPSS 20 and Graph Pad 5.0 software.Results:According to logistic regression analysis,NLR is an early predictor of acute kidney injury in patients with acute pancreatitis complicated infection.NLR,bedside index for severity in acute pancreatitis,and quick sequential organ failure assessment are of some significance in predicting acute kidney injury in patients with acute pancreatitis and infection.ROC curve analysis confirmed that the cutoff value of NLR for predicting acute kidney injury was NLR = 15.99(95% CI 0.193-0.618,sensitivity 60.0 %,Specificity is 81.8%).Conclusions:NLR is an early predictor of acute renal injury in patients with acute pancreatitis complicated infection.