Correlation Analysis Of Positive Deficiency And Blood Stasis Syndrome Types With Cell Immunity,Coagulation And Hemorheology In CKD3-4 Non-dialysis Patients

ObjectiveThe research aims to provide a theoretical basis for the evaluation of clinical efficacy of the disease and TCM syndrome differentiation by studying the correlation between the syndrome of positive deficiency and blood stasis in patients with stage CKD3-4 and its related laboratory indicators.MethodsThis experiment is a cross-sectional study,which includes non-dialysis patients with stage CKD3-4 who meet the requirements.The above patients are classified by TCM syndromes through a questionnaire.Deficiency clip dampness syndrome,wet stasis mutual syndrome type.Through statistical treatment of patients’ age and gender,as well as Scr,GFR,BUN,UA,coagulation,hemorheology,cellular immunity and other indicators,the analysis of the differences between laboratory indicators and TCM syndrome types using univariate analysis of variance;In the second step,119 patients were grouped according to blood stasis syndrome and non-blood stasis syndrome,positive deficiency syndrome and non-positive deficiency syndrome,and univariate analysis of variance and logistic regression analysis were performed again to explore the correlation between TCM syndrome types and laboratory indicators..Data statistics used SPSS 24.0,P> 0.05 means no statistical difference,P <0.05 means that the difference is statistically significant,and P <0.01 means that the difference is statistically significant.ResultsⅠ.Among the 119 non-dialysis patients with stage CKD3-4,the oldest was 74 years old and the youngest was 24 years old.The number of women is significantly less than that of men.There were no significant differences in gender and age between the three types of TCM syndromes of positive deficiency of blood stasis,positive deficiency of dampness,and dampness of stasis(P>0.05).Mainly young people.Ⅱ.There was no significant difference in Scr,GFR,UA,and BUN indicators between the positive deficiency of blood stasis syndrome,dampness of stasis syndrome,and the positive syndrome of deficiency of dampness and stasis of dampness.Ⅲ.The positive deficiency of blood stasis syndrome and positive deficiency of dampness syndrome were compared with the syndrome of dampness and stasis,and the differences in CD4,CD8,CD4 / CD8 and other indicators in cellular immunity were statistically significant(P<0.05),and the percentages of CD3 and B lymphocytes There was no significant difference in indicators such as the percentage of natural killer cells(P>0.05).Ⅳ.Compared with non-positive deficiency syndromes,the indexes of CD4,CD8,CD4 / CD8 have significant differences(P<0.01).There is a certain correlation between positive deficiency syndromes and CD4,CD8,and CD4 / CD8.Ⅴ.Compared with positive deficiency blood stasis syndrome and damp stasis syndrome,compared with positive deficiency clip dampness syndrome,the differences in indexes such as APTT,DD,and fibrinogen degradation products in coagulation were statistically significant(P<0.05);There were no significant differences in PT,INR and other indicators between the types(P>0.05).Among the hemorheological indicators,the whole blood viscosity shear rate 1,plasma viscosity,erythrocyte sedimentation index,erythrocyte aggregation index,low whole blood reduced viscosity reduction and other indicators have statistical significance(P <0.05),while whole blood viscosity shear rate 5.Whole blood viscosity shear rate 30,whole blood viscosity shear rate 200,hematocrit,whole blood high-cut relative index,whole blood low-cut relative index,ESR value K,whole blood high-cut reduced viscosity,red blood cell rigidity index There was no statistically significant difference in indicators such as erythrocyte deformation index and TK(P>0.05).Ⅵ.Compared with non-blood stasis syndrome,blood stasis syndrome,APTT,Fib,DD,fibrin(pro)degradation products and whole blood viscosity shear rate in blood rheology 1.Plasma viscosity,erythrocyte sedimentation rate,red blood cell aggregation index,Whole blood low-cut reduction viscosity and other indicators havesignificant differences(P<0.01),and blood stasis syndrome and Fib,DD,whole blood viscosity shear rate 1,plasma viscosity,erythrocyte sedimentation,red blood cell aggregation index,whole blood low-cut reduction Indexes such as viscosity are relevant.ConclusionⅠ.There are significant differences in CD4,CD8,CD4 / CD8 and other indicators between positive deficiency syndrome and non-positive deficiency syndrome in CKD patients(P<0.01).Positive deficiency syndrome has a certain correlation with CD4,CD8 and CD4 / CD8.Ⅱ.Blood stasis syndrome of CKD patients is correlated with Fib,D-D in blood coagulation indexes and whole blood viscosity shear rate in blood rheology 1.Plasma viscosity,erythrocyte sedimentation index,erythrocyte aggregation index,and low-cut reduction viscosity of whole blood.