Analysis The Change Of FeNo And Pulmonary Function With Mycoplasma Pneumoniae Pneumonia

Objective:To observe the changes of exhaled nitric oxide and pulmonary function at different time points in children with mycoplasma pneumonia and children with non-mycoplasma pneumonia.To evaluate the degree of lung injury caused by MP infection and to know the time when they return to normal levels.To provide experimental basis for standardized treatment and follow-up in recovery period of MPP children,so as to reduce the possibility of irreversible airway damage in MPP children.Methods:Thirty children aged 5 to 15 years old with MPP and thirty children without MPP who were hospitalized in the general pediatric ward from January to June in 2019 were selected as the study subjects.FeNO and pulmonary function were dynamically monitored at admission,1 month after discharge,and 3 months after discharge.Changes in FeNO and pulmonary function values in children with pneumonia were analyzed.Results:1.The change of FeNO: FeNO was increased in both groups at the time of admission,especially in MPP group,but there was no significant difference between the two groups(40.30 ± 14.83 ppb in MPP group,26.50 ± 13.79 ppb in non MPP group,P > 0.05).After treatment,FeNO of the two groups decreased and returned to normalrange at 1 month and 3 months after discharge(MPP group: 17.33±6.29 ppb at 1 month after discharge;non MPP group: 13.23±9.29 ppb at 1month after discharge).2.The change of pulmonary function:(1)large airway function: FVC,FEV1 and PEF decreased in different degrees at admission in MPP group and non MPP group(< 80%).MPP group was lower,and the difference of FVC and PEF between two group was statistically significant(P<0.05).After treatment,the pulmonary function indexes of the two groups increased gradually,reaching to the normal level(≥80%).(2)Small airway function: MEF25%,MEF50%,MEF75% and MMEF in the two groups decreased at the time of admission(< 65%),and MEF75% in the two groups had a statistically significant difference(P < 0.05),indicating that MP infection caused more severe damage to MEF75%.One month after the treatment,the MPP group did not reach the normal level(< 65%),while the non-MPP group reached the normal level(> 65%).The difference between the two groups was statistically significant(P < 0.05).Three months after discharge,all indexes of the two groups returned to normal level,and there was no significant difference between the two groups(P > 0.05).Conclusions: 1.At the time of admission,the FeNO level of MPP group was increased and it could be reduced to normal level at one month after discharge.Pulmonary function was decreased too.After treatment,the large airway ventilation function returned to normal at one month afterdischarge.However,the recovery of small airway ventilation function was slower than that of large airway,and it recovered to normal level at 3months after discharge;2.The FeNO level of non-MPP group children was higher than the normal level at the time of admission,and decreased to the normal level one month after discharge after treatment.Pulmonary function also decreased at the time of admission.After treatment,the large and the small airway ventilation function were both returned to normal at one month after discharge;3.FeNO increased in both groups at admission.Compared with other pathogens,M.pneumoniae infection has more serious effects on FVC,PEF and MEF.After treatment,both groups of children with large airway injury recovered at the same time,while the recovery of small airway injury in MPP group was slower than that in non MPP group.