Comparison Of Diode Laser Enucleation Versus Holmium Laser Enucleation Of The Prostate For The Treatment Of Benign Prostatic Hyperplasia:A Randomized Controlled Trial

Objective: To compare the clinical efficacy and safety between diode laser(980 nm)enucleation of the prostate(Di LEP)and holmium laser enucleation of the prostate(Ho LEP)for the treatment of benign prostatic hyperplasia(BPH).Methods: A total of 126 BPH patients in our hospital from December 2016 to December 2017 were enrolled in this study.They were randomized to the Di LEP group or Ho LEP group,which were administrated with Di LEP or Ho LEP treatment,respectively.The patient's characteristics,such as age,body mass index,comorbidities,prostate volume,and prostate-specific antigen,were recorded before surgery.The perioperative outcomes and complications were also compared.The maximum flow rate(Qmax),postvoid residual(PVR),international prostate symptom score(IPSS),and quality of life(Qo L)score were assessed at baseline and 3,6,12 months postoperatively.Results: No significant differences were observed for the patient's baseline characteristics between both groups.For the perioperative outcomes,including operative time,resected tissue weight,catheter duration,and hospital stay,no significant difference was found between the two groups.However,the Di LEP group showed less blood loss and decrease in hemoglobin compared with the Ho LEP group.The incidence of early or late complications was similar for both groups.The Qmax,PVR,IPSS,and Qo L for both groups of patients were dramatically improved after surgery.By comparing the Qmax,PVR,IPSS,and Qo L between the two groups,no significant differences were detected in the 3-,6-,or 12-month follow-up.Conclusions: This study demonstrated that both Di LEP and Ho LEP are efficient and safe treatments for BPH patients.What's more,Di LEP showed less blood loss and decrease in hemoglobin than Ho LEP,which indicated that diode laser(980 nm)generates a better hemostasis effect.