Copper Chaperone For Superoxide Dismutase Promotes Breast Cancer Cell Proliferation And Migration Via ROS-Mediated MAPK/ERK Signaling

Breast cancer is the first leading cause of cancer-related deaths in women worldwide.The high rate of distant metastasis often results in a rapidly fatal clinical outcome for this disease.Copper chaperone for superoxide dismutase(CCS)is a critical component of oxidation-reduction system and functions as a potential tumor promoter in several cancers.However,the function and clinical significance of CCS in breast cancer remain unclear.Here,we found that CCS expression was upregulated in breast cancer.Knocking down CCS attenuated the phosphorylation level of ERK1/2,and sequentially impaired breast cancer cell proliferation and migration.Conversely,overexpression of CCS would activate the activity of ERK1/2 and enhanced their proliferation and migration capacities.Interestingly,we found that knockdown CCS downregulated the activity of ERK1/2 mediated by the accumulation of reactive oxygen species(ROS),which lead to inhibiting cell proliferation and migration.In summary,these results indicated that CCS could promote the growth and migration of breast cancer cells via regulating the ERK1/2 activity mediated by the accumulation of ROS.