The Efficacy And Safety Of Percutaneous Microwave Ablation And Cryoablation In The Treatment Of Advanced Intrahepatic Cholangiocarcinoma

Objective: To compare the efficacy and safety of CT-guided percutaneous microwave ablation(MVA)and cryoablation in the treatment of advanced intrahepatic cholangiocarcinoma(ICC).Methods: Fifty ICC patients of three hospitals were included in this retrospective study from 2010 to 2017.Thirty-one patients underwent MWA,and nineteen patients underwent cryoablation.Technical success rate,objective response rate,overall survival and complication rates were compared between the ablation groups.Results:(1)The technical success rates,29(93.5%)of 31 MVA procedures versus18(94.7%)of 19 cryoablation procedures,were not significantly different between the ablation groups(P >0.999).Operation times of cryoablation group were longer than those of MVA group(<0.001).(2)One month after these treatments,objective response rates,27(93.1%)of 29 MVA procedures versus 15(83.3%)of 18 cryoablation procedures,were not significantly different between two groups(P >0.999).(3)The medium survival times,12(95%CI:9.6,14.4)months of MVA group versus 8(95%Cl:5.9,10.1)months of cryoablation group,were not significantly different.(4)The complication rates of cryoablation group were higher than those of MVA group in the area of hepatic pain(P =0.041),cacochylia(P =0.001),total bilirubin increase(P =0.011),infection(P =0.034).Conclusion: The efficacy of MVA and cryoablation in the treatment of advanced intrahepatic cholangiocarcinoma were not significantly different.,but MVA may be more safety than cryoablation.