Effect Of Lidocaine Infusion On Propofol Dosage And Postoperative Adverse Events In Children

Objective: To explore the effect of continuous intravenous infusion of lidocaine on perioperative propofol dosage,postoperative pain and extubation reactions in children with tonsillectomy.Methods: Eighty children with elective tonsillectomy were randomly divided into lidocaine group and control group,40 cases in each group.In the lidocaine group,intravenous injection of 1.5 mg / kg of lidocaine was given 5 minutes before induction of anesthesia,followed by continuous pump injection of 1.5 mg /(kg · h)of lidocaine until the end of the operation.The control group was infused with equal volume of normal saline.Record the total amount of propofol pumped during operation,the amount of opioid used after operation,the Wong-Baker facial expression grading score before operation,1h,2h,4h,8h,24 h after operation,before operation,immediately after extubation,1min,Mean arterial pressure(MAP)and heart rate(HR)at 5min and 10 min,and postoperative recovery.Results: Compared with the control group,the amount of propofol in the lidocaine group was significantly reduced during the operation(P <0.05);the Wong-Baker score of the lidocaine group at 1h,2h,4h,8h and 24 h after operation was significantly lower than that of the control group(P <0.05);Compared with the control group,the amount of opioid used in the lidocaine group was significantly reduced(P <0.05),mean arterial pressure(MAP)and heart rate(HR)in children immediately after extubation,1min,5min,10min)Is more stable(P <0.05),postoperative nausea and vomiting(PONV)within 24 hours is significantly reduced(P <0.05),but there is no difference in the recovery,extubation,hospitalization time,and other adverse reactions after extubation;No symptoms of lidocaine toxicity were seen in either group.Conclusion: Continuous infusion of lidocaine during the perioperative period is helpful to reduce the amount of propofol during operation,reduce the pain and opioid consumption after pediatric tonsillectomy,and the incidence of nausea and vomiting within 24 hours after surgery.There was no difference in the time and incidence of other adverse reactions after extubation.