Clinical Observation Of Acupuncture Combined With Finasteride In The Treatment Of Benign Prostatic Hyperplasia With Shen-Qi-Kui-Xu

Objective: To observe the clinical efficacy of acupuncture combined with finasteride in the treatment of the Benign Prostatic Hyperplasia(BPH)of Sheng-Qi-Kui-Xu.Methods: A randomized controlled clinical study was conducted.62 subjects who met the inclusion criteria and were admitted to the outpatient department of acupuncture and urology in our hospital from January 2019 to December 2019 were randomly divided into the experimental group and the control group according to the simple random number table.Patients with oral finasteride tablets(approval number: Merck(in the United States and Canada called Merck)research and development,production)with Qi-bi-fang(Qi hai,Da dun,San yin jiao and Guan yuan,Zhao hai,Tai chong),with finasteride tablets(approval number:Merck(in the United States and Canada called Merck)research and development,production)treatment.For 6 weeks,there was 1 course of treatment and 2 courses of observation.Postvoid residual volume PRV,international prostate symptom score(IPSS),prostate volume(PV)and adverse reactions during the project were recorded.SPSS 21.0 for Windows statistical software was used for statistical analysis of the collected data.Results: A total of 62 cases were included in this study,60 cases completed the clinical observation,2 cases were exfoliated,including 1 case in the treatment group and 1 case in the control group.(1)Comparison of total clinical response rate: after 12 weeks of treatment,the total response rate of the experimental group was 80.00%,of which the significant efficiency was10.00%.The total effective rate of the control group was 60.00%,of which the significant efficiency was 0%.There was a statistical difference in the efficacy between the two groups(Z=2.197,P=0.028 < 0.05).(2)Comparison of international prostate symptom score(IPSS): the difference between the experimental group and the control group in the improvement of IPSS score was statistically significant(F=5.330,P=0.025<0.05),and the difference in the effect at different time periods after treatment was statistically significant(F=152.200,P=0.00<0.05),which was the best 12 weeks after treatment,followed by 6 weeks.(3)Comparison of prostate volume: there was no statistically significant difference between the experimental group and the control group in the improvement of prostate volume(F=1.828,P=0.182>0.05),and there was a statistically significant difference in the effect at different time periods after treatment(F=27.471,P=0.000<0.05),presenting the best 12 weeks after treatment,followed by 6 weeks.(4)Comparison of bladder residual urine volume: the difference between the experimental group and the control group in improving bladder residual urine volume was statistically significant(F=4.417,P=0.040<0.05),and the difference in effect at different time periods after treatment was statistically significant(F=23.512,P=0.000<0.05),which was the best 12 weeks after treatment,followed by 6 weeks.(5)Safety comparison: no adverse reactions occurred in the two groups during the study period,and the safety indicators were all within the physiological range.There was no statistical difference in the comparison of safety indicators between the two groups after treatment(P>0.05).Conclusion: the combination of Qi-bi-fang and fenasteride tablets can significantly improve the clinical symptoms caused by BPH.It is a safe and effective treatment scheme forBPH and has a broad application prospect.