Independent Predictors For MVI In Stage Ⅰ Hepatocellular Carcinoma After Hepatectomy

ObjectiveTo investigate the independent predictors for MVI in stage Ⅰhepatocellular carcinoma after hepatectomy.MethodsThe retrospective analysis method was conducted.Patients with HCC admitted at Chongqing Medical University from January 2017 to February2019 were retrospectively reviewed and divided into the MVI negative and positive groups according to pathological results.General data,laboratory parameters and imaging data were collected.Continuous variables were compared using the t test or Mann-Whitney test.Categorical variables were compared using the χ~2 test or Fisher exact test.The ROC curve was used to determine cut-off value by maxing the Youden index and evaluate diagnostic efficacy.ResultsUnivariate analysis showed that hepatitis viral B(HBV)DNA(P=0.034),tumor size(P < 0.001),peritumoral enhancement(P=0.013),visible small blood vessels in the arterial phase(P=0.002)and distance from the tumor to the IVC(DTI)(P=0.004)were risk factors significantly associated with the presence of MVI.The area under the ROC curve for tumor size and DTI were 0.786 and 0.711,and the optimal cut-off value were 5.145 cm and 3.125 cm,respectively.Tumor size(OR = 2.911,95%CI 4.069-83.006;P<0.001)was independent predictors for MVI.ConclusionHBV DNA >10e3 IU/mL,tumor size >5.145 cm,peritumoral enhancement,visible small blood vessels in the arterial phase and DTI ≤3.125 cm were risk factors for microvascular invasion of hepatocellular carcinoma.Tumor size was independent risk factor for MVI formation.