Relationship Between Anemia And Trace Elements In 0-1 Year Old Infants And Its Effects On Neuropsychological Development In Lanzhou

Objective:To investigate the prevalence of anemia in infants aged 0-1 year old in Lanzhou,analyze the deficiency and excess of trace elements of calcium,iron,zinc,copper and magnesium,study the relationship between anemia and levels of trace elements of calcium,iron,zinc,copper and magnesium,and explore the effect of anemia on neuropsychological development.Methods:The study included 555 infants who had physical examination in the department of child healthcare,Lanzhou university first hospital from October 1,2016to September 30,2017.Blood routine and trace elements were analyzed.Pearson test was used to study the relationship between hemoglobin(Hb)and trace element levels.Among the 259 infants who had Gesell developmental assessment,53 infants werediagnosed as anemia.Seventy-one non-anemic infants were selected as the control group,and Gesell developmental score was compared.Statistical analysis of the data to explore the impact of anemia on neuropsychological development.Results:1.The current statue of infant anemia in this studyThe incidence of anemia in infants aged 0-1 years old in Lanzhou is 21.44%,among which the highest incidence is infants aged 6-9 months.Anemia type is mainly mild anemia,and the blood cell morphology of infants with anemia is mainly small cells with low pigment.The incidence of anemia was 20.51%in male infants and22.63%in female infants.There was no significant difference in the incidence of anemia in male and female infants(?~2=0.365,P=0.546).2.The analysis of the content of trace elements in infants in this study and the correlation analysis between Hb level and trace elementsTrace element deficiency rates ranged from high to low:iron 15.31%(85/555),calcium 11.89%(66/555),zinc 8.46%(47/555),copper and magnesium deficiency were not found.Trace element exceeding rate from high to low:iron 9.18%(51/555),zinc 7.56%(42/555).calcium,copper and magnesium excessive were not found.Hb level was positively correlated with iron level(r=0.159,P<0.05).Hb level was also positively correlated with zinc level(r=0.087,P<0.05).There was no correlation between Hb level and calcium,copper and magnesium levels(P>0.05).3.The comparison of infant trace elements between the anemia group and the control groupThe contents of iron and zinc in infant in the anemia group were significantly lower than those in the control group(t values were 3.80 and 2.00 respectively,all P<0.05).There was no statistically significant difference in calcium,copper and magnesium content between the two groups(t values were-0.51,0.57 and-0.43respectively,all P>0.05).4.The comparison of blood cell morphological parameters between the anemia group and the control groupThe Hb,MCV,MCH and MCHC values of infants in the anemia group were lower than those in the control group,and the differences were statistically significant(P<0.05).5.The score of the anemia group was compared with that of the control groupThe score of fine motor and gross motor in the anemia group was significantly lower than that in the control group(t=-2.11,-2.00,all P<0.05).There were no statistically significant differences in language ability,adaptive behavior and personal-social behavior score between the two groups(t=-0.68,-8.57,-0.54,all P>0.05).Conclusion:The trace elements of iron and zinc are both deficient and exceeded in infants aged 0-1 year old in Lanzhou,and calcium is deficient.Iron,zinc and anemia are positively related.Anemia can affect the development of gross motor and fine motor of the infants.