Study On Default Mode Network And Visual Network In Type 2 Diabetes Based On Independent Componentanalysis

PurposeTo investigate the changes of the brain network functional connectivity(FC)in type 2 diabetes mellitus(T2DM)patients by using independent component analysis(ICA).MethodsT2DM patients with(R~+,n=25)and without(R~-,n=22)retinopathy were recruited as T2DM group and 29 healthy controls(HCs group)were enrolled.Underwent resting-state fMRI scanning,the default mode(DMN)and visual(VIS)networks were selected through data preprocessing and ICA analysis to find the changes of brain network FC between groups.The correlation between FC scores in different brain regions and clinical parameters,cognitive scores were analyzed.Results(1)Compared with the HCs group,the FC of DMN in T2DM group significantly decreased in the left supplementary motor area and the left superior frontal gyrus,while increased in the bilateral medial cingulate cortex;the FC of VIS decreased in the right calcarine gyrus,the right cuneus cortex and bilateral lingual gyrus,but no FC of VIS increased.(2)Compared with the R~-group,no significant differences about the FC of DMN in R~+group;the FC of VIS decreased in the left calcarine gyrus,the right middle occipital gyrus and the right inferior parietal lobule,but no FC of VIS increased.(3)The FC scores of the right lingual gyrus were inversely correlated with the body mass index(BMI)(r=-0.434,P=0.003)in T2DM patients.ConclusionThe abnormal FC of DMN and VIS in T2DM patients may suggest the impairment of some brain networks especially the visual networks in R~+group,which may provide a possible imaging pathway for early diagnosis of cognitive dysfunction in T2DM.