Study On The Long-term Effect And Prognosis Of Concurrent Chemoradiotherapy And Surgical Comprehensive Treatment For Stage ⅡB Cervical Cancer

Objective:To compare the clinical effect and prognosis of surgical comprehensive treatment and concurrent chemoradiotherapy for stage ⅡB cervical cancer to provide reference of theory for clinical treatment.Method:In this retrospective study,147 patients with stage ⅡB cervical cancer from January 2013 to December 2016 in oncology department and gynecology department of First Affiliated Hospital of Chongqing Medical University were collected.In accordance to different treatment,they were divided into concurrent chemoradiotherapy group(CCRT group)(n=70)and surgical comprehensive treatment group(RH group)(n=77).The general clinical data,short/long-term complications,5-year progression-free survival(PFS)and overall survival(OS)were compared between the two groups.Assess factors that may have an impact onsurvival.Result:The rate of radiation enteritis and radiation cystitis in the CCRT group was higher than that in the RH group while the rate of lower limb edema in the RH group was higher than that in the CCRT group(P < 0.05).The5-year PFS of the CCRT group and the RH group were 75.2% and 83.6%,respectively,and the 5-year OS were 72.4% and 78.9%.There was no significant difference in survival curve(P > 0.05).Pathological type was a factor affecting the prognosis of stage ⅡB cervical cancer(P < 0.05).The overall survival and the progression-free survival of patients with squamous cell carcinoma was better than that of non-squamous cell carcinoma.Conclusion:1.The 5-year overall survival rate and 5-year progression-free survival rate of surgical comprehensive treatment are not inferior to that of concurrent chemoradiotherapy.2.Compared with concurrent chemoradiotherapy,surgical comprehensive treatment increased the risk of lower limb edema.However,it decreased the incidence of radiation enteritis and radiation cystitis.3.Pathological type was a factor affecting the prognosis of stage ⅡB cervical cancer.The overall survival and the progression-free survival of patients with squamous cell carcinoma was better than that ofnon-squamous cell carcinoma.