Effect Of Digital Subtraction Angiography On Attention Network Function In Patients With Minor Ischemic Stroke

Objective:The purpose of this study was to explore the effect of digital subtraction angiography(DSA)on attention network function in patients with minor ischemic stroke.Methods:The overall cognitive function of 20 patients with mild ischemic stroke who underwent DSA surgery(DSA group)and 15 patients without DSA(control group)was evaluated using the Mini-Mental State Examination(MMSE).The Attention Network Test(ANT)was used to assess the efficiency of the three attention network components,such as alertness,orientation,and executive control.In addition,we compared the effect in attentional network function between in the DSA group of patients before DSA and on the 5th day after DSA and the control group patients at the matching time points(time point 1 and time point 2)。Results:There was no statistically significant difference(P >0.05)in MMSE,anxiety and depression before the surgery between DSA surgery group and control group(non-DSA surgery group)at the matching time point.And no significant difference existed between these two groups in alerting network(27.95±32.19 vs 26.47±43.12milliseconds),orienting network(53.90±32.52 vs 52.67±26.31 milliseconds)and executive control network(157.20±94.68 vs 157.07±79.92 milliseconds).The reaction time of alerting network on the 5th day after surgery decreased significantly in DSA group patients compared with that before surgery(11.35±26.80 vs 27.95±32.19 milliseconds,P=0.010)while the RT increased significantly in control group patients at the matching time points(39.60±38.67 vs 26.47±43.12 milliseconds,P=0.035),there was no statistical difference in orienting network and executive control network at these two time points(P >0.05).With One-way ANCOVA controlling for the difference in baseline level,there was statistical difference in the effect on the alerting network efficiency between the two groups.The changes of alerting network efficiency in DSA group was significantly related to the changes of Hamilton Anxiety Rating Scale(P<0.001).Conclusion:DSA may damage the attention network function of patients with mild ischemic stroke to a certain extent,which is mostly reflected in the efficiency of ANT,mainly manifested as that patients cannot timely and sensitively receive external information stimulation.