Preliminary Study On The Removal Method Of Background Change In Noninvasive Blood Glucose Detection

Non-invasive blood glucose measurement based on near infrared spectroscopy is expected to achieve non-invasive and continuous monitoring of blood glucose levels in diabetic patients.It has good application prospects and social value.Near infrared diffuse reflectance spectroscopy(NIDRS)measurement based on position difference can reduce the interference of light source drift and man-machine interface changes in long-term measurement and improve the accuracy of continuous blood sugar monitoring.In practical applications,long-term measurements can be made up of discrete multiple short-term measurements,each 2-3 hours from the beginning of eating can be regarded as a short-term measurements.Large random changes in skin and man-machine interface may occur between different measurements,which will result in large measurement errors.In order to solve this problem,this paper studies the characteristics of human spectral changes in long-time measurement.Based on these changes,a preliminary spectral correction method is studied.The difference between several short-time measurements is eliminated by spectral correction,and the accuracy of blood sugar measurement is improved.The main work of this paper is as follows:Firstly,the measurement theory based on position difference diffuse reflectance spectroscopy is studied,and the application scope of this method for linear absorbance extraction is proposed.Furthermore,two strategies of spectral correction are proposed,one is to use orthogonal method for spectral correction,the other is to use linear correction.Then,the spectral characteristics of various interference factors in anthropometry were studied,including skin scattering coefficient,hemoglobin concentration,contact pressure between man-machine interface,body temperature and the difference of measurement site.The research methods include Monte Carlo simulation and human experiment.Furthermore,the spectral correction method proposed in this paper is used to correct the spectral data with interference,and the effectiveness of the correction method is examined.Including the use of orthogonal chemometrics and linear calibration methods,and linear calibration method used in OGTT human experimentpreliminary achieved good experimental results.In summary,this paper uses the position difference based diffuse reflectance spectroscopy method to analyze the spectral characteristics of various human interference factors,and focuses on the preliminary study of spectral correction methods.The results of this study can be preliminarily applied to long-term human blood glucose measurement,and promote the development of non-invasive blood glucose measurement to clinical application.