Expression And Clinical Value Of Small And Dense Low Density Lipoprotein In Cardiovascular Disease Of Rheumatoid Arthritis

Methods:All the cases in this study were collected from 233 patients admitted to the rheumatology department of the second hospital of shanxi medical university from May 2018 to December 2019 who were diagnosed with rheumatoid arthritis and were included in the case group,including 46 males and 20 females aged(56.880 ± 13.345).In addition,233 healthy physical examination subjects were selected as the control group,including 76 males and 157 females,aged(50.485±14.028).A total of 466 cases were reported.Detection of small,dense low-density lipoprotein cholesterol,total cholesterol,triglycerides,high-density lipoprotein cholesterol,low density lipoprotein cholesterol and apolipoprotein A1,apolipoprotein B100,apolipoprotein E,lipoprotein-alpha,creatine kinase,creatine kinase isoenzyme MB,lactate dehydrogenase,hydroxybutyric acid dehydrogenase,alanine aminotransferase,door winter transaminase,total bilirubin,direct bilirubin,etc.Laboratory test results were recorded and grouped strictly according to inclusion and exclusion criteria.The results of RA case group and control group were compared and the data were processed with appropriate statistical methods to obtain results.Results: 1.The level of small and dense LDL in patients with rheumatoid arthritis was significantly higher than that in the control group,and the difference was statistically significant.2.Small and dense LDL may be a risk factor for developing dyslipidemia,atherosclerosis,and eventually cardiovascular disease in patients with rheumatoid arthritis,and it is affected by apolipoprotein B100,lipoprotein-cholesterol,and age.Both Lpa and sdLDL had good diagnostic efficacy in RA,and the efficacy of age index in RA was good,while the efficacy of ApoB index in disease diagnosis was poor.Conclusion: The increased serum volume of sdldl-c in rheumatoid arthritis patients can be used to explain the phenomenon that nearly half of rheumatoid arthritis patients die from cardiovascular diseases due to its strong atherogenic effect.Apolipoprotein B100,lipoprotein-cholesterol and age had effects on sdLDL,and lipoprotein-cholesterol-cholesterol and age had greater effects on sdLDL.Therefore,sdLDL can be combined with ApoB,LPa and patient age for early assessment of the risk of atherosclerosis in RA patients.