Correlation Between Serum GFAP And Tau Proteins And Severity Of Spinal Cord Injury In Patients With Traumatic Spinal Cord Injury

OBJECTIVE: To investigate the correlation between the changes in the content of glial fibrillary acidic protein(GFAP)and microtubule associated protein Tau(Tau)in serum after traumatic spinal cord injury(TSCI),It is expected to provide a quick and accurate diagnosis of clinical conditions.Methods: In this trial,37 patients with acute spinal cord injury treated in our hospital from 2017.12 to 2019.12 were selected as the spinal cord injury group,28 patients with simple spinal fractures were selected as the simple fracture group,and 30 healthy adults were randomly selected as the control group.All patients were graded A-D by ASIA when they were admitted to the hospital.Samples were collected at 12 h,24h,3d,7d,and 14 d after injury,and the control group collected samples once.All samples were uniformly tested for GFAP and Tau protein content after centrifugation.Results: The above samples were comprehensively compared through data analysis.The results showed that the serum GFAP and Tau protein levels in the spinal cord injury group were significantly higher than those in the simple fracture group and the healthy control group(P <0.05).There was no significant difference in serum GFAP and Tau protein levels between the control group and the healthy control group(P> 0.05);there were significant differences in serum GFAP and Tau protein concentrations in different time periods in the spinal cord injury group(P <0.05),and the protein concentration gradually increased with time.GFAP protein gradually decreased after reaching the peak on 3d,and Tau protein gradually decreased after reaching the peak on 7d;patients with different ASIA grades had significant differences in serum GFAP protein content(P <0.05),the higher the level,the more protein content High;patients with complete spinal cord injury and incomplete spinal cord injury have significant differences in serum Tau protein content(P <0.05).The more severe the injury,the higher the protein content.Conclusions: GFAP protein: 1.Spinal cord injury can cause the increase of GFAP protein in the serum,and the more serious the injury,the higher the concentration;2.GFAP protein in the serum can better distinguish ASIA-B and ASIA-C from each ASIA grade Patients,positively correlated with the severity of the injury;3.The serum GFAP protein concentration in patients with spinal cord injury significantly increased with the time of injury,peaked at 3d,and fell back to the level of 12 h after 14d;4.Simple spinal fractures will not Cause changes in serum GFAP protein concentration;5.GFAP protein is present in small amounts in the serum of healthy adults and patients with simple spinal fractures.Tau protein: 1.Spinal cord injury can cause the increase of Tau protein in serum,and the more severe the injury,the higher its concentration;2.Tau protein in serum can better distinguish patients with complete spinal cord injury and incomplete spinal cord injury;3 Spinal cord injury patients' serum Tau protein concentration gradually increased with the time of injury,reached a peak at 7 days,and fell to the level of injury 12-24 h in the next 7 days;4.Simple spinal fractures will not cause serum Tau protein concentration Changes;5.Tau protein is present in small amounts in the serum of healthy adults and patients with simple spinal fractures.