Risk Factors And Prognosis Of Post-infarction Left Ventricular Aneurysm Related Ventricular Tachyarrhythmias

Objective To explore the risk factors and prognosis of ventricular tachyarrhythmias in patients with post-infarction left ventricular aneurysm.Methods Retrospective analysis wa s performed on the data of 147 inpatients admitted to the general hospital of Ningxia Medical University who were Diagnosed as PI-LVA on January 1,2016,solstice,and January 31,2019,according to whether it is combined with ventricular tachyarrhythmias(VTA),The samples were divided into VTA group(42 cases)and no-VTA group(105 cases).The univariate and multivariate logistic regression analysis was used to determine independent predictors of VTA development in PI-LVA patients.In addition,patients in VTA group were followed up by telephone and outpatient for an average of 22.93±10.22 months.The primary study end points included sudden cardiac death,appropriate ICD shocks and external cardioversion due to sustained ventricular tachycardia / fibrillation with hemodynamic collapse.Establishing Cox proportional hazards model to analyze the influencing factors of clinical outcome.Kaplan-Meier method was used for survival analysis and cardiac survival curve,and log-rank test was used for comparison.To comprehensively evaluate the clinical outcome of VTA group.Results 1.Compared with non VTA,VTA group had larger LVEDD and Tpeak-Tend interv al,lower LVEF,and higher rate in chronic kidney disease,chronic obstructive pulmonar y disease(COPD),homocysteine,NYHA Ⅲ-Ⅳ,LVEF<35%,inferior myocardial infarction,frequent ventricular extrasystole,multivessel disease,atrial fibrillation,and fQRS(P<0.05).2.The single-factor Logistic regression analysis demonstrates that the proportion of LVEDD>55,LVEF<35%,Tpeak-Tend interval increase,inferior myocardial i nfarction,frequent ventricular extrasystole,multivessel disease,atrial fibrillation,moderate/se vere mitral regurgitation,chronic kidney disease,and COPD in VTA group was higher t han that in non VTA group.The multi-factor logistic regression analysis demonstrates t hat NYHA Ⅲ-Ⅳ,inferior myocardial infarction,frequent ventricular extrasystole,chronic kidney disease,and COPD is a strong predictor of VTA in PI-LVA.3.Kaplan-Meier analysis showed that chronic kidney disease significantly reduced s urvival in PI-LVA with VTA.Conclusion 1.NYHA Ⅲ-Ⅳ,inferior myocardial infarction,frequent ventricular extrasystole,chronic kidney disease,and COPD is a potential predictors for VTA in pi-lva patients.2.In VTA group,chronic kidney disease is an independent predictor of poor clinical outcome.