Study Of FMRI In The Brain Of Patients With Chronic Insomnia In Xining Area

Objective:Chronic insomnia affects people’s memory,immunity and cognition.Xining area is located at a high altitude,and the incidence of insomnia is higher under chronic hypoxia.Therefore,the purpose of this study is to use f MRI to explore changes in brain structure and function in patients with chronic insomnia.Methods: Thirty patients with chronic insomnia and thirty healthy volunteers with matching high altitude(about 2200-3000 m above sea level),age,and years of education age were enrolled.Brain structure images(MP2RAGE)and resting state functional magnetic resonance images were collected from all subjects on a 3.0T MRI scanner(MAGNETOM Prisma,Siemens).The SMS-BOLD sequence was processed using VBM,Re Ho,ALFF method and comparison between groups to extract GMV、Re Ho、and ALFF values in different brain regions.Results:Compared with the normal control group,the chronic insomnia group had decreased GMV in bilateral fusiform gyrus,bilateral cerebelum lobules6,bilateral lingual gyrus,left Calcarine gyrus,left cerebelum lobules1,left wedge,left Occipital gyrus,and had no significant increase in GMV;the chronic insomnia patients group had decreased Re Ho in right Fusiform gyrus,right Para Hippocampal gyrus,right Hippocampus gyrus,right emporal＿Pole＿Sup gyrus,and increased Re Ho in right Amygdala gyrus;the chronic insomnia patients group had decreased ALFF in the bilateral cerebellum lobules Crus2,Crus1,8 and left cerebellum lobules7b,and increased ALFF in right rcerebellum lobules7b.Conclusion:Patients with chronic insomnia at high altitude have multiple structural and functional changes in their brain regions.