Study On The Related Factors Affecting Thecurative Effect Of Colorectal Cancer

Objective:To evaluate the prognostic value of combined detection of platelet lymphocyte ratio(PLR)and serum carcinoembryonic antigen(CEA)in patients with colorectal cancer before operation.Methods:The overall survival of 186 patients with colorectal cancer admitted to Shanghai Sixth People’s Hospital from September 2012 to September 2013 was analyzed retrospectively.Select the sex,age,tumor location,differentiation degree,tumor size,TNM stage,preoperative peripheral blood CEA,platelet and lymphocyte values and other clinical data of the study subjects and the overall survival of patients after surgery correlation analysis(focusing on preoperative CEA and PLR combined,stratified analysis),screening related factors affecting the prognosis of colorectal cancer.Clinical data were analyzed by SPSS20.0 software.The relationship between clinical factors was judged byχ2 test.The cumulative survival rate was calculated by Kaplan Meier method and survival curve was drawn.COX regression analysis was used to find out the factors affecting the prognosis of patients with colorectal cancer.Results:1.Preoperative CEA and PLR were significantly correlated with the depth of tumor invasion and TNM staging(P<0.05).2.Survival analysis showed that patients with colorectal cancer had poor prognosis when the degree of differentiation of tumors was low,the stage of tumors was late,CEA positive in peripheral serum before operation and PLR positive in peripheral blood platelet/inflammatory lymphocyte ratio(P<0.05).The overall survival rate was 45.45%in the strong positive group,57.89%in the weak positive group and 79.31%in the negative group.The overall 5-year survival rate was higher in the CEA negative group(χ2=17.44,P<0.05).The overall survival rate was 54.76%in the weak positive group and 54.76%in the weak positive group.The overall survival rate was 82.54%in the negative group.The overall survival rate in the PLR negative group was higher than that in the strong positive group(χ2=19.1,P<0.01).0.05).Combined analysis:5-year overall survival rate was 85.45%in CEA and PLR negative group,44%in double-positive group and 25%in double-strong positive group(x2=29.65,P<0.05).It is suggested that the prognosis is better when the above two indicators are negative.3.COX multivariate regression analysis showed that TNM stage and tumor differentiation were independent risk factors for prognosis of patients with colorectal cancer.Preoperative serum CEA positive,inflammatory lymphocyte ratio(PLR)positive and their combined detection are related factors for prognosis of patients with colorectal cancer,but not independent risk factors.CONCLUSION:Preoperative blood CEA and peripheral platelet/inf-1 ammatory lymphocyte ratio(PLR)are related factors affecting the pro-gnosis of patients with colorectal cancer,and combined detection can provide important reference value for judging the prognosis of patients with colorectal cancer.Objective: To investigate the effect of different surgical methods on colorectal cancer.Methods:The clinicopathological data of 186 patients with colorectal cancer admitted to Shanghai Sixth People’s Hospital from September 2012 to September 2013 were retrospectively analyzed.According to the different surgical methods,they were divided into laparotomy group and laparoscopy group,including 110 cases in laparotomy group and 76 cases in laparoscopy group.The short-term and long-term effects of bleeding volume,operation time,hospital stay,exhaust time,indwelling catheter time,eating fluids time,WBC count,blood tumor markers,length of resected intestine,complication rate,number of lymph node dissection and 3-5-year overall survival rate were compared between the two groups.Result: The short-term therapeutic effects of laparoscopic group were better than those of laparotomy group in terms of intraoperative blood loss,hospital stay,exhaust time,indwelling catheter time,feeding fluids time,WBC count and total complication rate(P < 0.05),while the length of resected intestinal canal,number of lymph node dissection and CEA index one month after operation were significantly different between the two groups(P < 0.05).There was no significant difference in the overall survival rate between 3 and 5 years after operation(P >0.05).Conclusion: Compared with the two methods,laparoscopic resection of colorectal cancer has obvious advantages in short-term recovery and low incidence of complications.However,there is no significant difference in the long-term survival after operation,which needs further study.