Long-term Efficacy Of Transcatheter Patent Foramen Ovale Closure In Alleviating Migraine

Background:The association between patent foramen ovale(PFO)and migraine has been reported.However,whether transcatheter PFO closure is effective in alleviating migraine remains controversial.The objective of this study was to investigate the efficacy of PFO closure in alleviating migraine in a 5-year follow-up.Materials and Methods:Migraineurs with PFO from 2013 to 2015 were included and divided into PFO closure group and non-PFO closure group according to their therapy.Contrastenhanced transcranial Doppler(c-TCD)was performed to evaluate the degree of the right-to-left shunt(RLS),and headache impact test(HIT-6)questionnaire was administered to assess the disability of migraine at 1-and 5-year follow-up.Results:Of 192 patients,91 patients underwent PFO closure,and 101 patients refused.The HIT-6 scores of patients in the PFO closure group were significantly lower than those of the non-PFO closure group at both 1-and 5-year follow-up.These results were more pronounced in patients younger than 45 years and in patients who had migraine less than 10 years.Furthermore,in patients with large RLS,the HIT-6 scores of patients in the PFO closure group were significantly lower at both 1-and 5-year follow-up compared with those of the non-PFO closure group.However,in patients with moderate RLS,this difference was significant only at 5-year follow-up.Conclusions:PFO closure is effective in alleviating migraine in the long term.This effect is more obvious when patients are younger than 45 years,course of migraine is less than 10 years and RLS is large.