The Correlation Between Frailty And Cardiac Structure And Function In Elderly Patients

Objectives:Cardiovascular disease(CVD)is a common disease in the elderly.Previous studies have suggested that frailty is associated with the morbidity and mortality of CVD,and frailty may worsen the prognosis of patients with CVD.However,at present,the effect of cardiac structure and function on the frailty in the elderly is not clear.Therefore,the purpose of this study is to explore the relationship between frailty and cardiac structure and function in elderly patients.Methods:(1)Study subjects: this study is a cross-sectional observational study,which collected229 inpatients aged ≥60 years from November 2018 to May 2019 in the ward of the First Hospital of Jilin University.(2)Study methods: the subjects were divided into two groups according to the FRAIL score,of which the score of 3-5 was Frailty Group,and the score of <3 was Non-Frailty Group.The demographic data,complications,laboratory test results,and echocardiographic data of the selected patients were collected.(3)Statistical analysiss: statistical analysis was performed using SPSS 24.0 software.The measurement data that conforms to the normal distribution are expressed as mean ±standard deviation,and the comparison between two groups uses independent sample t test;the count data and rank data are expressed as percentages,and the comparison between two groups uses Chi-squared test or rank sum test;subgroup analysis was performed by age stratification,measurement data and grade data that did not meet the normal distribution were compared using the rank sum test;analysis of the influencing factors of frailty used binary logistic regression;spearman correlation analysis was used to test the correlation betweenFRAIL score and continuous variable or grade data,P <0.05 was considered statistically significant.Results:A total of 229 elderly patients were included in this study,The average age was 79.09±10.15 years,including 167 males and 62 females.(1)According to the FRAIL score,there were 102 cases in the Frailty Group and 127 cases in the Non-Frailty Group.The age(P<0.001),malignant tumors(P<0.001),blood urea nitrogen(P=0.014),and blood creatinine(P=0.033)of the Frailty Group were significantly higher than the Non-Frailty Group;the hemoglobin(P<0.001),alanine aminotransferase(P=0.040),albumin(P<0.001),and low density lipoprotein cholesterol(LDL-C)(P=0.045)of the Frailty Group were significantly lower than the Non-Frailty Group,and the difference was statistically significant(P<0.05).After stratification of age,the incidence of frailty was different among different age subgroups,and the difference was statistically significant(P<0.001).Spearman correlation analysis showed a positive correlation between FRAIL score and age(r=0.602,P<0.001).(2)The left atrial diameter(P<0.001)and E/e’ >15(P<0.001)were significantly higher in the Frailty Group than the Non-Frailty Group,with statistically significant differences(P<0.05).After stratification by age,the left atrial diameter(P<0.001)and E/e’ >15(P=0.001)had statistically significant differences between the age subgroups(P<0.05).Spearman correlation analysis showed that FRAIL score was positively correlated with left atrial diameter(r=0.436,P<0.001)and E/e’(r=0.367,P<0.001).(3)Taking the frailty as the dependent variable,age,malignant tumors,hemoglobin,alanine aminotransferase,albumin,blood urea nitrogen,blood creatinine,LDL-C,left atrial iameter,and E/e’ as the independent variables,the binary logistic regression analysis showed that,Age(P<0.001),malignant tumors(P=0.034),left atrial iameter(P=0.006)and E/e’(P=0.006)were risk factors for elderly frailty patients(P<0.05).Conclusion:(1)Frailty in elderly patients is age-related,and the risk of frailty increases with age.(2)The degree of frailty is significantly related to left atrial diameter and left ventricular diastolic function,and older patients with larger left atrial diameter and left ventricular diastolic dysfunction have an increased risk of frailty.