Study On The Correlation Between Plasma 3-nitrotyrosine Level And Cognitive Function Change In Patients With High White Matter Signaling

Objective Plasma levels of 3-nitrotyrosine(3-NT)were measured,and the relationship between these levels and cognitive changes in patients with high white matter signal was predicted by different results in different populations.Methods A total of 122 patients with high white matter signal were included except cerebral infarction,admitted to the department of neurology,the first affiliated hospital of shihezi university school of medicine from October 2018 to May 2019,T2 FLAIR high signal based on nuclear magnetic results.All enrolled patients were graded according to the mini-mental State Examination(MMSE),According to the score,the patients were divided into the white matter high-signal group and the white matter high-signal group combined with cognitive impairment group,plasma concentrations of 3-nitrotyrosine in the two groups were determined by enzyme-linked immunosorbent assay(ELISA),the correlation between plasma 3-nitrotyrosine concentration and cognitive function in patients with high white matter signal was further analyzed.Results The plasma 3-NT concentrations of the control group and the cognitive impairment group were(49.713±4.77)nmol/L and(98.4399±23.14)nmol/L,The plasma 3-nt concentration in the cognitive impairment group was significantly higher than that in the control group(P<0.05);The triglycerides of the control group and the cognitive impairment group were(1.3605±0.59147)mmol/L and(1.6229±0.78477)mmol/L,The cognitive impairment group was significantly higher than the control group(P<0.05),3-NT and triglyceride were included in Logistic multiple regression analysis.There was significant statistical significance of 3-nt(P<0.01),and statistical significance of triglyceride(P<0.05).Conclusions The determination of plasma 3-NT concentration may be used as a biochemical indicator of cognitive impairment in patients with high white matter signal,the detection of 3-NT concentration is expected to be an effective indicator for predicting cognitive decline in patients with high white matter signals.There were differences in triglycerides in white matter with and without high signal levels,but it was not an independent risk factor for cognitive changes in patients with high white matter signals.