| At present,cancer is still one of the most important causes of human death.The current treatment methods mainly include: surgical treatment,radiation treatment,chemotherapy,biotherapy,traditional Chinese medicine treatment and heat treatment.However,the main treatment methods are traditional surgical treatment,radiation treatment and chemotherapy.As a new type of therapy,hyperthermia mainly uses infrared,ultrasonic,high-frequency electromagnetic wave to generate heat source for tumor thermal treatment.Not only can it kill tumor cells,but it can also be used as an adjunct to improve the efficacy of chemotherapy and radiotherapy.Microwave hyperthermia(MH)uses the thermal effect of microwaves in the wavelength range of 300 MHz-300 GHz to heat up the tumor area and treat the tumor.Microwave thermotherapy antennas are divided into non-invasive antennas and invasive antennas.Non-invasive antennas use a single antenna or an array antenna to gather energy to the tumor site and heat the tumor tissue to achieve the purpose of treatment.Non-invasive antennas have shallow thermal penetration and can only be used for the treatment of superficial tumors.For tumors deep in the human body(such as liver,lung,etc.),the antenna is directly inserted into the tumor area for heating treatment,that is,an invasive antenna.Due to the different shapes of tumors,the use of a hyperthermia antenna alone cannot accurately heat only the tumor site and easily damage surrounding normal tissues.Therefore,while designing microwave thermotherapy antennas,it is important to develop microwave heat-sensitizing materials to assist microwave thermotherapy antennas in treating tumors.Metal-organic framework(MOF)materials are widely used in tumor treatment due to their adjustable size,porous structure,and good microwave heating effect.Because of its low toxicity,good biodegradability and other advantages,it has become one of the first choice materials for tumor treatment drug carriers.MOF materials easily penetrate into the tumor stroma and accumulate at the tumor site through enhanced permeability and retention(EPR)effect.Therefore,it can be used as a microwave hyperthermia sensitizer to assist microwave hyperthermia antennas in treating tumors.In this paper,an array antenna with a working frequency of 2450 MHz is designed by using HFSS simulation software.Through optimization and simulation,the value of S11 of array antenna at 2450 MHz frequency point is-15.68 dB.The electric field distribution and SAR distribution show that the array antenna can achieve a wide range of heating effect.Based on this,a kind of ZrMOF-Cys nanoparticles with good heating effect and low toxicity was designed.And because of the EPR of ZMC NPs,it can be enriched in tumor sites.The combination of the array antenna and ZMC NPs shows that the combination therapy could concentrate the heat treatment energy on the tumor location,with little damage to the surrounding normal tissues.It has excellent therapeutic effect.The main research contents of the paper include:1.Overview of domestic and foreign research status of hyperthermia antennas and MOF materials.A brief introduction to the different types of antennas currently used in hyperthermia.And the introduction of MOF materials for tumor treatment.2.Design an array antenna that can achieve large area heating.Because the size and shape of the tumors are different,the designed array antenna must be heated in a large area.It is then combined with MOF materials to achieve the purpose of conformal hyperthermia.3.Design of MOF materials with good heating effect.ZrMOF-Cys nano-particles were prepared,which had a significant effect of heating under microwave heating.And its particle size is small and its toxicity is low.It can be safely used for in vivo treatment.4.Microwave hyperthermia experiment.Through body film experiments and animal experiments,it is further verified that the array antenna combined with ZrMOF-Cys nanoparticles has a good therapeutic effect and can achieve the purpose of conformal hyperthermia. |
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