| Objective:The purpose was to use digital subtraction angiography to make a verify diagnosis of patients diagnosed with moyamoya disease by magnetic resonance angiography,analyze the factors that may cause differences in the diagnosis of moyamoya disease,and provide a basis for clinical diagnosis.Method:A total of 122 patients from the first affiliated hospital of Nanchang University who were diagnosed as MMD by MRA from January 2019 to January 2020 and underwent DSA verification diagnosis later were collected.Diagnostic criteria were based on the MMD diagnosis and treatment guidelines issued by Japan in 2012.Detailed clinical data of the patients were collected,including gender,age,homocysteine,thyroid function,uric acid,low-density lipoprotein,triglyceride,syphilis antibody,history of hypertension,history of diabetes,carotid artery plaque examination results,clinical manifestations and intracranial vascular conditions.According to the diagnosis results of DSA,122 research subjects were divided into consistent result group(both MRA and DSA were positive,99 cases)and different result group(MRA was positive and DSA was negative,23 cases).According to gender,age,homocysteine,thyroid function,uric acid,low density lipoprotein,triglyceride,syphilis antibody,history of hypertension,history of diabetes,clinical manifestations and vascular occlusion.Two groups of patients were classified and treated by a comparative analysis.All data were analyzed by spss26.0 statistical software,age was represented by,and independent sample t test was used forcomparison between the two groups;the data of categorical variables were expressed as frequency and percentage(%),and the comparison between groups adopted ?2 test.Through independent sample t test and chi-square test,the independent variables with statistical significance were initially screened out for the test,and then the bestindependent variables were selected by stepwise regression method and substituted into the binary Logistic regression analysis to further analyze the correlation of these factors with the MMD diagnosis.That the P value <0.05 was statistically significant.Results:(1)A total of 122 adult patients were included in this study,where the ratio of male to female was 1.3: 1 and the average age was 51.98 ± 8.506 years old.Consistent result group included 99 people,where the ratio of male to female was 1.2:1 and the average age was 51.48±8.428 years old;inconsistent result group included23 people,where the ratio of male to female was 1.5:1 and the average age was 54.09±8.707 years old.(2)The first clinical manifestations of MMD were diverse.Cerebral ischemia was the main clinical manifestation of MMD,accounting for 68.7%.(3)The consistency between MRA and DSA for MMD diagnosis was 81.1%,and the consistent rate between MRA rating and Suzuki classification was 82.8%.(4)For patients with MMD prompted by MRA,in the case that high triglycerides,carotid plaques,diabetes,and MRA scores were not in the range of 2-7 points,there were differences in the diagnosis of moyamoya disease between the two groups.Conclusion:(1)In China,the prevalence rate of MMD was similar between men and women,which was about 1.2:1.The most common clinical manifestation was cerebral ischemia;(2)As a non-invasive detection method,3.0T MRA had the advantages of economy and simplicity,with a greater role in guiding the vascular classification of moyamoya disease;(3)Among patients positive for MRA diagnosis of moyamoya disease,the positive rate of DSA was 81.1%,and the two detection methods were highly consistent.However,patients with high triglycerides,carotid plaques,diabetes,and MRA scores of 1 or 8-10 were recommended to improve DSA examination. |
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